Summanwar Diana, Kim Hyena, Wei Jingkai, Boustani Malaz, Alonso Alvaro, Kulshreshtha Ambar
Department of Family Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Family and Preventive Medicine, Emory University, Atlanta, GA, USA.
J Alzheimers Dis Rep. 2025 Aug 21;9:25424823251370646. doi: 10.1177/25424823251370646. eCollection 2025 Jan-Dec.
We analyzed how cardiovascular disease subtypes influence the prevalence and incidence of dementia among 30,582 individuals aged 50 and older in the National Alzheimer's Coordinating Center cohort. We calculated prevalence ratios (aPR) and hazard ratios (aHR), using models adjusted for age, sex, race, years of education, hypertension, diabetes, and dyslipidemia. Stroke (aPR: 1.26; 95% CI: 1.20-1.32) and history of arrhythmias (aPR: 1.17; 95% CI: 1.09-1.24) were associated with higher dementia prevalence. In survival analysis, stroke was associated with a 55% increased risk of incident dementia (aHR: 1.55; 95% CI: 1.36-1.77).
我们在国家阿尔茨海默病协调中心队列中，分析了心血管疾病亚型如何影响30582名50岁及以上个体的痴呆症患病率和发病率。我们计算了患病率比（aPR）和风险比（aHR），使用了根据年龄、性别、种族、受教育年限、高血压、糖尿病和血脂异常进行调整的模型。中风（aPR：1.26；95%置信区间：1.20-1.32）和心律失常病史（aPR：1.17；95%置信区间：1.09-1.24）与较高的痴呆症患病率相关。在生存分析中，中风与新发痴呆症风险增加55%相关（aHR：1.55；95%置信区间：1.36-1.77）。
