中年血脂异常与痴呆症终生发病率之间的关系：队列研究的系统评价和荟萃分析
The relationship between midlife dyslipidemia and lifetime incidence of dementia: A systematic review and meta-analysis of cohort studies.
作者信息
Wee Jason, Sukudom Sara, Bhat Saiuj, Marklund Matti, Peiris Niridu Jude, Hoyos Camilla M, Patel Sanjay, Naismith Sharon L, Dwivedi Girish, Misra Ashish
机构信息
Fiona Stanley Hospital South Metropolitan Health Service Perth Western Australia Australia.
University of Western Australia Perth Western Australia Australia.
出版信息
Alzheimers Dement (Amst). 2023 Mar 8;15(1):e12395. doi: 10.1002/dad2.12395. eCollection 2023 Jan-Mar.
INTRODUCTION
We conducted a systematic review and meta-analysis to review the relationship between midlife dyslipidemia and lifetime incident dementia.
METHODS
The databases Medline, Embase, Scopus, Web of Science, and Cochrane were searched from inception to February 20, 2022. Longitudinal studies examining the relationship between midlife lipid levels on dementia, dementia subtypes, and/or cognitive impairment were pooled using inverse-variance weighted random-effects meta-analysis.
RESULTS
Seventeen studies (1.2 million participants) were included. Midlife hypercholesterolemia was associated with increased incidence of mild cognitive impairment (effect size [ES] = 2.01; 95% confidence interval [CI] 1.19 to 2.84; = 0.0%) and all-cause dementia (ES = 1.14; 95% CI: 1.07 to 1.21; = 0.0%). Each 1 mmol/L increase in low-density lipoprotein was associated with an 8% increase (ES = 1.08, 95% CI: 1.03 to 1.14; I = 0.3%) in incidence of all-cause dementia.
DISCUSSION
Midlife dyslipidemia is associated with an increased risk of cognitive impairment in later life.
引言
我们进行了一项系统评价和荟萃分析，以研究中年血脂异常与终生发生痴呆症之间的关系。
方法
检索了Medline、Embase、Scopus、Web of Science和Cochrane数据库，检索时间从数据库建立至2022年2月20日。使用逆方差加权随机效应荟萃分析汇总了研究中年血脂水平与痴呆症、痴呆症亚型和/或认知障碍之间关系的纵向研究。
结果
纳入了17项研究（120万参与者）。中年高胆固醇血症与轻度认知障碍发病率增加相关（效应量[ES]=2.01；95%置信区间[CI]为1.19至2.84；I²=0.0%）以及全因痴呆症（ES=1.14；95%CI：1.07至1.21；I²=0.0%）。低密度脂蛋白每升高1 mmol/L，全因痴呆症发病率增加8%（ES=1.08，95%CI：1.03至1.14；I²=0.3%）。
讨论
中年血脂异常与晚年认知障碍风险增加相关。
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