Tian Rongqian, Qiu Shaona, Zhang Jinrong, Chen Ming, Yu Hai, Lau Waichi, Lyu Jun, Deng Liehua
Department of Dermatology, The First Affiliated Hospital of Jinan University & Jinan University Institute of Dermatology, Guangzhou, China.
Jinan University Institute of Dermatology, Guangzhou, China.
Front Immunol. 2025 Aug 11;16:1620027. doi: 10.3389/fimmu.2025.1620027. eCollection 2025.
Increasing evidence suggests that metabolic syndrome (MetS) may contribute to the development of psoriasis. However, the mediating role of accelerated aging in this association remains unclear.
This study utilized data from 319,263 participants in the UK Biobank. Cox proportional hazards models were used to assess the associations between MetS, genetic predisposition, and psoriasis risk. Mediation analysis examined the role of accelerated aging (PhenoAgeAccel) in the relationship between MetS, its components, and psoriasis.
MetS was associated with a 30% increased risk of psoriasis (HR: 1.30; 95% CI: 1.20-1.40). Among its components, abdominal obesity, low HDL cholesterol, high triglycerides, and hyperglycemia were each independently linked to higher risk. Individuals with both MetS and high genetic susceptibility had a substantially increased risk (HR: 2.93; 95% CI: 2.51-3.43). PhenoAgeAccel significantly mediated 28.8% of the MetS-psoriasis association.
MetS and its components play a key role in psoriasis development, especially in genetically susceptible individuals. Accelerated aging may partially explain this link, suggesting a potential biological pathway and underscoring the importance of early MetS identification.
越来越多的证据表明，代谢综合征（MetS）可能促进银屑病的发展。然而，加速衰老在这种关联中的中介作用仍不清楚。
本研究使用了英国生物银行中319263名参与者的数据。采用Cox比例风险模型评估MetS、遗传易感性与银屑病风险之间的关联。中介分析考察了加速衰老（PhenoAgeAccel）在MetS及其组分与银屑病关系中的作用。
MetS与银屑病风险增加30%相关（风险比：1.30；95%置信区间：1.20 - 1.40）。在其组分中，腹型肥胖、低高密度脂蛋白胆固醇、高甘油三酯和高血糖各自独立地与更高风险相关。同时患有MetS和高遗传易感性的个体风险大幅增加（风险比：2.93；95%置信区间：2.51 - 3.43）。PhenoAgeAccel显著介导了MetS与银屑病关联的28.8%。
MetS及其组分在银屑病发展中起关键作用，尤其是在遗传易感个体中。加速衰老可能部分解释了这种联系，提示了一条潜在的生物学途径，并强调了早期识别MetS的重要性。
