Romisher Alison, Kopelson Jordyn, Milgraum Sandy
Dermatology, Robert Wood Johnson University Hospital, New Brunswick, USA.
Dermatology, Cooper Medical School of Rowan University, Camden, USA.
Cureus. 2025 Jul 24;17(7):e88684. doi: 10.7759/cureus.88684. eCollection 2025 Jul.
Erythema annulare centrifugum (EAC) is a type of figurate erythema with an unclear etiology, often thought to be a delayed hypersensitivity reaction to various antigens. While many cases resolve spontaneously, chronic and refractory presentations can be challenging to manage. We report a case of EAC unresponsive to traditional treatments but demonstrating rapid improvement with upadacitinib, a selective Janus kinase (JAK) inhibitor. This case highlights a novel use for JAK inhibitors in treating EAC.
离心性环状红斑（EAC）是一种病因不明的环状红斑，通常被认为是对各种抗原的迟发型超敏反应。虽然许多病例可自发缓解，但慢性和难治性病例的治疗可能具有挑战性。我们报告了一例对传统治疗无反应，但使用选择性 Janus 激酶（JAK）抑制剂乌帕替尼后迅速改善的 EAC 病例。该病例突出了 JAK 抑制剂在治疗 EAC 中的新用途。
