Dandash Zeinab, Mobayed Tala, Temraz Sally, Shamseddine Ali, Doughan Samer, Deeba Samer, Ayoub Zeina, Eid Toufic, Youssef Bassem, Hilal Lara
Department of Radiation Oncology, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon.
Department of Hematology-Oncology, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon.
Curr Oncol. 2025 Aug 7;32(8):443. doi: 10.3390/curroncol32080443.
Treatment of locally advanced rectal cancer (LARC), clinical stages II-III, typically involves multimodal treatment options. Over the past decade, the role of radiation therapy as a neoadjuvant treatment for LARC has evolved and is currently a part of total neoadjuvant therapy (TNT). Some recently published studies advocate for the omission of radiation therapy entirely, while others report on a non-operative approach that emphasizes the use of higher radiation therapy doses. This review aims to evaluate the latest literature on the current role of radiation therapy in the management of LARC, with a discussion of how to best select the most appropriate treatment protocol based on individual patient and tumor characteristics, comorbidities, and personal needs and preferences.
局部晚期直肠癌（LARC，临床分期为II - III期）的治疗通常涉及多模式治疗方案。在过去十年中，放射治疗作为LARC新辅助治疗的作用不断演变，目前已成为全新辅助治疗（TNT）的一部分。一些最近发表的研究主张完全省略放射治疗，而另一些研究则报道了一种强调使用更高放射治疗剂量的非手术方法。本综述旨在评估关于放射治疗在LARC管理中当前作用的最新文献，并讨论如何根据个体患者和肿瘤特征、合并症以及个人需求和偏好，最佳地选择最合适的治疗方案。
