Novaković Josip, Barišić Ana, Šuvak Erik, Dragaš Emili, Drviš Petar, Mendeš Tihana, Ajduk Jakov, Maslovara Siniša, Košec Andro
Department of Otorhinolaryngology, General Hospital Zabok, 49210 Bračak, Croatia.
Health Care Centre Zagreb West, 10110 Zagreb, Croatia.
Audiol Res. 2025 Aug 6;15(4):99. doi: 10.3390/audiolres15040099.
: Meniere's disease is characterized by a triad of vertigo episodes, fluctuating hearing loss, and tinnitus. The disease is followed by a loss of quality of life in patients, with the severity depending on the individual and the stage of the disease. Since there are no quantitatively validated tests that connect all elements of the disease, the only source of subjective data that can be analyzed is the disease diary and questionnaires, among which the MDPOSI (Meniere's Disease Patient-Oriented Symptom-Severity Index) stands out as a designated quality-of-life assessment tool. This study aims to evaluate the differences in the questionnaire depending on the clinical characteristics of the disease. : The study recruited 60 patients, with clinical variables including age, gender, disease laterality, caloric testing results, and PTA results, the presence of spontaneous nystagmus, pathological values of calorimetric testing, or rotatory chair testing abnormalities. : The appearance of spontaneous nystagmus showed a significant association with worse hearing threshold values at 500 Hz ( = 0.036, OR 4.416) and higher. Worse SRT scores correlated with Q1 ( = 0.011), Q2 ( = 0.028), Q4 ( = 0.045), Q5 ( = 0.013), and the total MDPOSI score ( = 0.008, 0.339). Multivariate analysis showed that a higher total value of the MDPOSI questionnaire was statistically significantly associated with older age ( = 0.042) and spontaneous nystagmus ( = 0.037). : There is a correlation between the clinical characteristics of Meniere's disease and the MDPOSI questionnaire, making it useful for assessing quality of life and disease progression.
梅尼埃病的特征是眩晕发作、波动性听力损失和耳鸣三联征。该疾病会导致患者生活质量下降，严重程度因个体和疾病阶段而异。由于没有能够关联该疾病所有要素的经过定量验证的测试，唯一可分析的主观数据来源是疾病日记和问卷，其中梅尼埃病患者导向性症状严重程度指数（MDPOSI）作为指定的生活质量评估工具脱颖而出。本研究旨在评估根据疾病临床特征，问卷之间的差异。：该研究招募了60名患者，临床变量包括年龄、性别、疾病侧别、冷热试验结果和纯音听阈结果、自发性眼震的存在、冷热试验的病理值或转椅试验异常。：自发性眼震的出现与500Hz及更高频率时更差的听力阈值显著相关（P = 0.036，OR = 4.416）。更差的言语识别率得分与问题1（P = 0.011）、问题2（P = 0.028）、问题4（P = 0.045）、问题5（P = 0.013）以及MDPOSI总分相关（P = 0.008，r = 0.339）。多因素分析表明，MDPOSI问卷的更高总分在统计学上与年龄较大（P = 0.042）和自发性眼震（P = 0.037）显著相关。：梅尼埃病的临床特征与MDPOSI问卷之间存在相关性，这使得它对于评估生活质量和疾病进展很有用。
