海参衍生生物活性物质在预防和管理脑相关疾病中的治疗潜力：综述

Therapeutic Potential of Sea Cucumber-Derived Bioactives in the Prevention and Management of Brain-Related Disorders: A Comprehensive Review.

作者信息

Debi Purnima Rani, Barua Hrishika, Ahmmed Mirja Kaizer, Bhowmik Shuva

机构信息

Department of Fish Biology and Biotechnology, Faculty of Fisheries, Chattogram Veterinary and Animal Sciences University, Chattogram 4225, Bangladesh.

Department of Fishing and Post-Harvest Technology, Faculty of Fisheries, Chattogram Veterinary and Animal Sciences University, Chattogram 4225, Bangladesh.

出版信息

Mar Drugs. 2025 Jul 30;23(8):310. doi: 10.3390/md23080310.

DOI:10.3390/md23080310

PMID:40863627

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12387399/

Abstract

The popularity of bioactive compounds extracted from sea cucumbers is growing due to their wide application in the pharmaceutical industry, particularly in the development of drugs for neurological disorders. Different types of compounds, such as saponins, phenolic compounds, cerebrosides, and glucocerebrosides, are being studied intensively for their efficacy in assessing the treatment of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and brain tumors, among others. Positive results have been observed in the upregulation in the content of p-CREB, p-PL3K, BDNF, SOD, and MDA. Furthermore, the neuroprotective mechanism of the compounds against Alzheimer's disease revealed that suppressing the phosphorylation of tau protein by the PI3K/Akt/GSK3β pathway leads to improved synaptic plasticity and reduced nerve fiber tangles. This comprehensive review explores recent findings on the therapeutic potential of sea cucumber bioactives in the treatment of brain-related disorders.

摘要

从海参中提取的生物活性化合物越来越受欢迎，因为它们在制药行业有广泛应用，特别是在神经疾病药物开发方面。不同类型的化合物，如皂苷、酚类化合物、脑苷脂和葡萄糖脑苷脂，正因其在评估神经退行性疾病（包括阿尔茨海默病、帕金森病和脑肿瘤等）治疗效果方面的功效而受到深入研究。在p-CREB、p-PL3K、BDNF、SOD和MDA含量上调方面已观察到积极结果。此外，这些化合物针对阿尔茨海默病的神经保护机制表明，通过PI3K/Akt/GSK3β途径抑制tau蛋白的磷酸化可改善突触可塑性并减少神经纤维缠结。这篇综述探讨了海参生物活性物质在治疗脑部相关疾病方面治疗潜力的最新研究结果。