Mølsæter Katarina, Roth Kjetil, Myklebust Tor Åge, Hermansen Erland, Singh Dave, Currie Crawford, Hoff Dag Arne Lihaug
Department of Health Sciences, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), P.O. Box 1517, 6025 Ålesund, Norway.
Department for Research and Innovation, Møre og Romsdal Hospital Trust (HMR), P.O. Box 1600, 6026 Ålesund, Norway.
Mar Drugs. 2025 Aug 15;23(8):328. doi: 10.3390/md23080328.
Asthma is a heterogeneous chronic respiratory condition with distinct inflammatory phenotypes, including type 2-driven eosinophilic asthma. This randomized, double-blind, placebo-controlled exploratory trial investigated the effects of OmeGO, on respiratory outcomes in adults with type 2 asthma. Over a 20-week period, 66 participants received 6 g per day of either OmeGO (≥120 mg eicosapentaenoic acid (EPA), ≥180 mg docosahexaenoic acid (DHA)), or placebo. The key outcome was a composite score of moderate and severe exacerbation events. Asthma control was assessed using the Asthma Control Questionnaire-5-item (ACQ5) and the Global Initiative for Asthma (GINA) criteria. The median time to the first composite event was 37 days (95% CI 9-47) in the OmeGO group and 15 days (95% CI 12-33) in the placebo group ( = 0.347); 73% of the participants in the OmeGO experienced at least one exacerbation compared to 82% in the placebo group ( = 0.347). The weekly frequence of composite events was 0.36 per day in the OmeGO group and 0.32 in the placebo group ( = 0.777). Even though there are no differences in the exacerbation rates between groups, the time to first composite event should be further explored.
哮喘是一种具有不同炎症表型的异质性慢性呼吸道疾病，包括2型驱动的嗜酸性粒细胞性哮喘。这项随机、双盲、安慰剂对照的探索性试验研究了OmeGO对2型哮喘成年患者呼吸结局的影响。在20周的时间里，66名参与者每天接受6克OmeGO（≥120毫克二十碳五烯酸（EPA），≥180毫克二十二碳六烯酸（DHA））或安慰剂。关键结局是中度和重度加重事件的综合评分。使用哮喘控制问卷5项（ACQ5）和全球哮喘防治创议（GINA）标准评估哮喘控制情况。OmeGO组首次出现综合事件的中位时间为37天（95%CI 9-47），安慰剂组为15天（95%CI 12-33）（P=0.347）；OmeGO组73%的参与者至少经历了一次加重，而安慰剂组为82%（P=0.347）。OmeGO组综合事件的每周发生率为每天0.36次，安慰剂组为0.32次（P=0.777）。尽管两组之间的加重率没有差异，但首次出现综合事件的时间仍应进一步探讨。
