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在一家三级护理医院心脏科门诊就诊的心力衰竭患者中药物依从性和合理性的评估:一项横断面观察性研究。

Evaluation of Medication Adherence and Appropriateness Among Heart Failure Patients Attending the Cardiac Clinic at a Tertiary Care Hospital: A Cross-Sectional Observational Study.

作者信息

Bagyawantha Nanayakkara Muhandiramalaya Yasa Kalum, Dangahage Isuri Nilnuwani, Mayurathan Ghanamoorthy, Suminda Pushpika Weerasinghe Mudiyanselage

机构信息

Department of Pharmacy, Faculty of Allied Health Sciences, University of Peradeniya, Peradeniya 20400, Central Province, Sri Lanka.

National Hospital Kandy, Kandy 20000, Sri Lanka.

出版信息

Pharmacy (Basel). 2025 Jul 27;13(4):101. doi: 10.3390/pharmacy13040101.

Abstract

Heart failure is a chronic disease with significantly high morbidity and mortality rates, and a thorough understanding of medication adherence and appropriateness is crucial to ensure effective treatment outcomes. This cross-sectional observational study aimed to assess medication adherence, understand the influence of sociodemographic factors on medication adherence, and assess the medication appropriateness for heart failure patients attending the cardiac clinic at National Hospital Kandy (NHK). This study was conducted among 325 heart failure patients attending the cardiac clinic at the NHK. Medication adherence was assessed using the brief medication questionnaire (BMQ) after detailed medication history interviews. Statistically significant associations between total BMQ scores and sociodemographic factors were determined at 95% confidence interval. The appropriateness of the newly prescribed medication lists was assessed using the medication appropriateness index (MAI). Among the 325 patients recruited, the mean total BMQ score was 1.16; 11.7% of the participants were adherent to their medications whereas 15.4% had poor adherence. Most participants (52.0%) were in the probable poor adherent level. Statistically significant associations were observed between total BMQ score and age, sex, and education level. The mean MAI score was 0.56. Medication adherence among heart failure patients was poor and some sociodemographic factors influenced medication adherence. The appropriateness of prescribed medications was found to be acceptable.

摘要

心力衰竭是一种发病率和死亡率极高的慢性疾病,全面了解药物依从性和合理性对于确保有效治疗效果至关重要。这项横断面观察性研究旨在评估药物依从性,了解社会人口学因素对药物依从性的影响,并评估康提国立医院(NHK)心脏科门诊心力衰竭患者的用药合理性。本研究在325名前往NHK心脏科门诊的心力衰竭患者中进行。在详细的用药史访谈后,使用简短用药问卷(BMQ)评估药物依从性。在95%置信区间确定总BMQ得分与社会人口学因素之间具有统计学意义的关联。使用用药合理性指数(MAI)评估新开具的药物清单的合理性。在招募的325名患者中,总BMQ平均得分为1.16;11.7%的参与者坚持服药,而15.4%的参与者依从性差。大多数参与者(52.0%)处于可能依从性差的水平。在总BMQ得分与年龄、性别和教育水平之间观察到具有统计学意义的关联。MAI平均得分为0.56。心力衰竭患者的药物依从性较差,一些社会人口学因素影响药物依从性。发现所开药物的合理性是可以接受的。

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