Guilbault L A, Thatcher W W, Collier R J, Wilcox C J, Drost M
J Anim Sci. 1985 Dec;61(6):1516-26. doi: 10.2527/jas1985.6161516x.
Effects of fetal sire on postpartum reproductive changes of the dam were studied in 21 Holstein heifers whose pregnancy had been initiated by either Angus (n = 7), Holstein (n = 7) or Brahman (n = 7) bulls. After parturition, all heifers were managed uniformly. Heifers in each service-sire-breed group were bled via jugular venipuncture thrice weekly from d 160 to 265 of pregnancy, daily thereafter until 15 d postpartum, and three times per week until d 60 postpartum. Ability of heifers to release prolactin (PRL) and luteinizing hormone (LH) was evaluated on d 10 postpartum after a simultaneous injection of thyrotropin releasing hormone (TRH; 100 micrograms) and gonadotropin releasing hormone (GnRH; 100 micrograms). Between d 5 and 60 postpartum, the reproductive tract of each heifer was examined rectally thrice weekly after collection of blood samples. Basal concentrations of LH from d 1 to 10 postpartum, as well as ability of the pituitary gland to release LH and PRL after the GnRH-TRH challenge, did not differ between service-sire-breed groups (P greater than .1). Means and profiles of progesterone concentrations during the first 60 d postpartum did not differ between service-sire-breed groups (P greater than .1). However, increases in progesterone concentrations following the GnRH-TRH challenge were synchronized more precisely in Angus (P less than .02) than in Holstein- and Brahman-service-sire groups. Daily rates of reduction in cervical and uterine horn diameters were higher (P less than .01) in Holstein- and Brahman- than in Angus-service-sire groups and were associated with higher profiles of postpartum 15-keto-13,14-dihydro-prostaglandin F2 alpha (PGFM) concentrations. Within-cow PGFM concentrations were correlated positively with cervical (r = .36) and uterine horn (r = .32) diameters. Postpartum ovarian responsiveness and uterine involution in Holstein heifers may be affected by genotypes of the conceptus they bore during pregnancy.
在21头荷斯坦小母牛中研究了胎儿父亲对母牛产后生殖变化的影响，这些小母牛的怀孕分别由安格斯公牛（n = 7）、荷斯坦公牛（n = 7）或婆罗门公牛（n = 7）授精。分娩后，所有小母牛均统一管理。每个配种公牛品种组的小母牛在妊娠第160天至265天每周经颈静脉采血3次，此后至产后15天每天采血，直至产后60天每周采血3次。在产后第10天，同时注射促甲状腺激素释放激素（TRH；100微克）和促性腺激素释放激素（GnRH；100微克）后，评估小母牛释放催乳素（PRL）和促黄体生成素（LH）的能力。在产后第5天至60天期间，每次采集血样后，每周经直肠检查每头小母牛的生殖道3次。产后第1天至10天LH的基础浓度，以及GnRH-TRH激发后垂体释放LH和PRL的能力，在配种公牛品种组之间没有差异（P＞0.1）。产后前60天孕酮浓度的平均值和变化曲线在配种公牛品种组之间没有差异（P＞0.1）。然而，GnRH-TRH激发后孕酮浓度的升高在安格斯组比在荷斯坦和婆罗门配种公牛组中更精确同步（P＜0.02）。荷斯坦和婆罗门配种公牛组中小母牛宫颈和子宫角直径的每日缩小率高于安格斯配种公牛组（P＜0.01），且与产后15-酮-13,14-二氢前列腺素F2α（PGFM）浓度的较高变化曲线相关。母牛体内PGFM浓度与宫颈直径（r = 0.36）和子宫角直径（r = 0.32）呈正相关。荷斯坦小母牛产后的卵巢反应性和子宫复旧可能受其妊娠期间所怀胎儿基因型的影响。
