Santorelli Adriano, Salti Giovanni, Cavallini Maurizio, Fundarò Salvatore Piero, Basso Matteo, Ponzo Martina, Avvedimento Stefano, Uderzo Stefano
"Santorelli and Partners", Via Raffaele Morghen, 88, 80129 Napoli, NA, Italy.
Independent Researcher, Via Claudio Monteverdi, 2, 50144 Firenze, FI, Italy.
Toxins (Basel). 2025 Jul 28;17(8):372. doi: 10.3390/toxins17080372.
Patient care following botulinum toxin injections has long been guided by anecdotal instructions, often based on theoretical considerations. This study evaluates the necessity of extended post-treatment instructions by analyzing outcomes and satisfaction in patients who followed only a 10 min precaution protocol.
A retrospective, multicentric study was conducted across six Italian centers, analyzing 5014 patients treated with botulinum toxin for upper facial wrinkles between 2015 and 2020. Outcomes included adverse effects-particularly upper eyelid ptosis-and patient satisfaction. Follow-up was performed at two weeks.
No cases of upper eyelid ptosis were observed. Among 4000 patients who attended follow-up, adverse effects occurred in only 5.99%, notably lower than rates reported in the literature. Of the 2010 patients who completed the satisfaction questionnaire, 90% reported being very satisfied. These findings support the safety of limiting post-treatment instructions to 10 min.
Our findings indicate that omitting extended post-injection instructions does not negatively impact patient satisfaction or complication rates. Given the toxin's rapid internalization and localized effect, extended behavioral restrictions may be redundant. However, the absence of a control group and lack of statistical analyses limit the strength of these conclusions. In addition, this is a short-term study. Future prospective, randomized trials are needed to develop evidence-based post-care protocols to optimize esthetic outcomes, patient safety, and long-term efficacy.
长期以来，肉毒杆菌毒素注射后的患者护理一直遵循传闻性的指导，这些指导往往基于理论考量。本研究通过分析仅遵循10分钟预防方案的患者的治疗结果和满意度，评估延长治疗后指导的必要性。
在意大利的六个中心进行了一项回顾性多中心研究，分析了2015年至2020年间接受肉毒杆菌毒素治疗上睑皱纹的5014例患者。结果包括不良反应——尤其是上睑下垂——以及患者满意度。随访在两周时进行。
未观察到上睑下垂病例。在4000例参加随访的患者中，不良反应发生率仅为5.99%，显著低于文献报道的发生率。在2010例完成满意度问卷的患者中，90%表示非常满意。这些发现支持将治疗后指导限制在10分钟的安全性。
我们的研究结果表明，省略延长的注射后指导不会对患者满意度或并发症发生率产生负面影响。鉴于毒素的快速内化和局部作用，延长行为限制可能是多余的。然而，缺乏对照组和统计分析限制了这些结论的力度。此外，这是一项短期研究。未来需要进行前瞻性随机试验，以制定基于证据的护理后方案，以优化美学效果、患者安全和长期疗效。
