Izeli Portilho Amanda, De Gaspari Elizabeth
Centro de Imunologia do Instituto Adolfo Lutz, São Paulo, SP, Brasil; Programa de Pós-Graduação Interunidades em Biotecnologia, Universidade de São Paulo, São Paulo, SP, Brasil.
Biomedica. 2025 Aug 11;45(3):359-368. doi: 10.7705/biomedica.7423.
Neisseria meningitidis is the main cause of bacterial meningitis worldwide and is transmitted through respiratory secretions. Meningitis is a serious public health problema because of its high morbidity and mortality rates and the risk of causing epidemics. Although vaccines are available to prevent meningococcal disease, serogroup B infections are still challenging, given that many countries do not include meningococcal B vaccines in their national immunization programs. In addition, recent data suggests somewhat sustained N. meningitidis B infections during the COVID-19 pandemic and increasing levels of meningococcal disease after its control. These findings agree with previous observations indicating that respiratory viruses facilitate respiratory bacterial infections. This essay intends to present epidemiological data on meningococcal disease and discusses studies exploring why the prevention of bacterial and viral infections is an intricate subject.
脑膜炎奈瑟菌是全球细菌性脑膜炎的主要病因,通过呼吸道分泌物传播。脑膜炎是一个严重的公共卫生问题,因为其发病率和死亡率很高,且有引发疫情的风险。尽管有疫苗可预防脑膜炎球菌病,但鉴于许多国家在其国家免疫规划中未纳入B群脑膜炎球菌疫苗,B群感染仍然具有挑战性。此外,最近的数据表明,在新冠疫情期间,B群脑膜炎奈瑟菌感染有所持续,疫情得到控制后脑膜炎球菌病水平有所上升。这些发现与之前的观察结果一致,即呼吸道病毒会促进呼吸道细菌感染。本文旨在介绍脑膜炎球菌病的流行病学数据,并讨论探讨为何预防细菌和病毒感染是一个复杂课题的研究。