Culler Steven D, Reynolds Matthew R, Kugelmass Aaron D, Katz Marc R, Simon April W, Cohen David J
Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Department of Economics and Quality of Life Research, Baim Institute for Clinical Research, Boston, Massachusetts, USA.
JACC Adv. 2025 Aug 26;4(9):102107. doi: 10.1016/j.jacadv.2025.102107.
Transcatheter aortic valve replacement (TAVR) has become the leading form of aortic valve replacement, with nearly 100,000 annual procedures in the United States. However, the impact of complications on hospital costs is not well understood.
The purpose of this study was to quantify the additional hospital resource use and costs associated with TAVR complications.
Medicare Provider Analysis and Review file from fiscal year 2020 identified 66,893 beneficiaries undergoing TAVR. International Classification of Diseases-10th-Clinical Modification diagnostic and procedure codes were used to identify complications and hospital costs were calculated using cost-to-charge ratios. Multivariable regression estimated the incremental cost and length of stay (LOS) associated with complications.
In 2020, 31.1% of the 66,893 Medicare beneficiaries who underwent a TAVR experienced one or more complications. The mean cost of a TAVR hospitalization was $54,988 ± $26,744 and the mean LOS was 3.1 ± 4.5 days. Patients who experience any of the complications increased costs by $15,377 and incremental LOS by 2.8 days compared to those not experiencing complications. After adjustments for patient risk factors, the incremental cost of complications was $12,953. Surgical aortic valve replacement ($42,924), acute renal failure requiring dialysis ($34,606), and in-hospital mortality ($25,307) had the highest risk-adjusted costs. Complications accounted for $320 million in additional costs, representing 8.7% of the total hospital cost for Medicare TAVR patients.
In contemporary practice, approximately one in 3 Medicare TAVR patients experience serious complications, substantially increasing hospital resource use. Despite improvements in TAVR outcomes and efficiency, additional cost savings can be achieved through complication mitigation.
经导管主动脉瓣置换术(TAVR)已成为主动脉瓣置换的主要方式,在美国每年有近10万例手术。然而,并发症对医院成本的影响尚不清楚。
本研究的目的是量化与TAVR并发症相关的额外医院资源使用和成本。
2020财年的医疗保险提供者分析和审查文件确定了66893名接受TAVR的受益人。使用国际疾病分类第十版临床修正版诊断和程序代码来识别并发症,并使用成本收费比率计算医院成本。多变量回归估计了与并发症相关的增量成本和住院时间(LOS)。
2020年,66893名接受TAVR的医疗保险受益人中有31.1%经历了一种或多种并发症。TAVR住院的平均成本为54988美元±26744美元,平均住院时间为3.1±4.5天。与未发生并发症的患者相比,发生任何并发症的患者成本增加了15377美元,住院时间增加了2.8天。在对患者风险因素进行调整后,并发症的增量成本为12953美元。外科主动脉瓣置换术(42924美元)、需要透析的急性肾衰竭(34606美元)和住院死亡率(25307美元)的风险调整成本最高。并发症导致额外成本3.2亿美元,占医疗保险TAVR患者总医院成本的8.7%。
在当代实践中,大约三分之一的医疗保险TAVR患者会出现严重并发症,大幅增加了医院资源的使用。尽管TAVR的结果和效率有所改善,但通过减轻并发症仍可实现额外的成本节约。