Colmenares-Mejia Claudia C, Bautista-Nino Paula K, Quintero-Lesmes Doris C, Riaño Carlos, Satizabal Jose Maria, Hu Jie, Gray Kathryn J, Serrano Norma C
Basic Science School, Health Faculty, Universidad del Valle, Cali, Colombia.
Research Centre, Fundación Cardiovascular de Colombia - (FCV), Centro Internacional de Especialistas, Valle de Menzuly Km 7, Piedecuesta, Santander Bucaramanga, Colombia.
Sci Rep. 2025 Aug 27;15(1):31615. doi: 10.1038/s41598-025-00154-8.
Extra-large HDL molecules (average diameter 14.3 nm) were inversely associated with preeclampsia. Additionally, extremely (particle diameters from 75 nm upwards) and very large (average diameter 64 nm) VLDL metabolites were associated with an increased the risk of preeclampsia. These findings provide evidence of molecules of interest for establishing risk or developing potential therapeutic targets" to "Specifically, extra-large HDL molecules (average diameter 14.3 nm) were inversely associated with preeclampsia, whereas extremely large (≥75 nm) and very large (average diameter 64 nm) VLDL metabolites were associated with an increased risk. These findings highlight distinct lipoprotein-related metabolic signatures linked to preeclampsia and suggest potential targets for risk assessment and therapeutic intervention.
超大高密度脂蛋白分子（平均直径14.3纳米）与先兆子痫呈负相关。此外，极大型（直径75纳米及以上）和非常大的（平均直径64纳米）极低密度脂蛋白代谢物与先兆子痫风险增加有关。这些发现为确定风险或开发潜在治疗靶点提供了相关分子的证据。具体而言，超大高密度脂蛋白分子（平均直径14.3纳米）与先兆子痫呈负相关，而极大型（≥75纳米）和非常大的（平均直径64纳米）极低密度脂蛋白代谢物与风险增加有关。这些发现突出了与先兆子痫相关的独特脂蛋白相关代谢特征，并提示了风险评估和治疗干预的潜在靶点。
