Haksari Ekawaty Lutfia, Irawan Gatot, Lusyati Setya Dewi, Wibowo Tunjung, Yunanto Ari, Rukmono Prambudi, Sianturi Pertin, Alasiry Ema, Primadi Aris, Basalamah M, Etika Risa, Wilar Rocky, Dharmasetiawani Nani
Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, Indonesia.
Faculty of Medicine, Diponegoro University/Dr. Kariadi Hospital, Semarang, Indonesia.
Sci Rep. 2025 Aug 27;15(1):31607. doi: 10.1038/s41598-025-16401-x.
The first month of life is the most vulnerable period for child survival. Newborns who are born too soon or too small, or sick, are at the greatest risk of death. Objective of the study was to delve into neonatal mortality and low birth weight (LBW) survival at hospitals in Indonesia. It was a retrospective cohort on the neonates cared at 12 hospitals in various islands of Indonesia during August-October 2021. Inclusion criteria were singleton and age 0-28 days, whereas exclusion criteria were incomplete medical records and gestational age ≥ 42 weeks. Of 2726 neonates, 2017 were eligible for the study. Multivariate logistic regression analysis exhibited LBW had the highest mortality risk, followed by referral neonates. The highest mortality risks at birth were asphyxia and major congenital abnormalities, subsequently. During the early neonatal period, the highest mortality risks were respiratory distress and feeding problem, consecutively. At 7-28 days of life, the feeding problem was the highest mortality risk. Kaplan Meier analysis suggested early neonatal death in LBW and Normal Birth Weight (NBW) infants was almost similar at aged 6 days. At neonatal period, however, the average age of neonatal death in LBW infants was 21 days, whereas in NBW 26 days.
生命的第一个月是儿童生存最脆弱的时期。早产、体重过轻或患病的新生儿死亡风险最高。本研究的目的是深入探讨印度尼西亚各医院的新生儿死亡率和低出生体重（LBW）存活率。这是一项对2021年8月至10月期间在印度尼西亚各岛屿的12家医院接受护理的新生儿进行的回顾性队列研究。纳入标准为单胎且年龄在0至28天之间，排除标准为医疗记录不完整和孕周≥42周。在2726名新生儿中，2017名符合研究条件。多因素逻辑回归分析显示，低出生体重儿的死亡风险最高，其次是转诊新生儿。出生时最高的死亡风险依次为窒息和主要先天性异常。在新生儿早期，最高的死亡风险依次为呼吸窘迫和喂养问题。在出生后7至28天，喂养问题是最高的死亡风险。Kaplan Meier分析表明，低出生体重儿和正常出生体重（NBW）婴儿在6天时的早期新生儿死亡率几乎相似。然而，在新生儿期，低出生体重儿的平均死亡年龄为21天，而正常出生体重儿为26天。
