• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
FOXM1-AXL/eEF2K Targeting: A Promising Treatment Strategy for Glioblastoma Multiforme Tumors.FOXM1-AXL/eEF2K靶向：一种针对多形性胶质母细胞瘤的有前景的治疗策略。
Cancers (Basel). 2025 Aug 15;17(16):2662. doi: 10.3390/cancers17162662.
2
Inhibition of FOXM1 Leads to Suppression of Cell Proliferation, Migration, and Invasion Through AXL/eEF2 Kinase Signaling and Induces Apoptosis and Ferroptosis in GBM Cells.抑制FOXM1通过AXL/eEF2激酶信号传导导致细胞增殖、迁移和侵袭受到抑制，并诱导胶质母细胞瘤细胞凋亡和铁死亡。
Int J Mol Sci. 2025 Jul 15;26(14):6792. doi: 10.3390/ijms26146792.
3
eEF2K is a poor prognostic factor and novel molecular target in pancreatic cancer: regulating tumor growth and progression via the tumor microenvironment.真核生物延伸因子2激酶（eEF2K）是胰腺癌中一个预后不良的因素和新的分子靶点：通过肿瘤微环境调节肿瘤生长和进展。
Cell Death Dis. 2025 Jul 7;16(1):501. doi: 10.1038/s41419-025-07803-w.
4
FoxM1 inhibition sensitizes resistant glioblastoma cells to temozolomide by downregulating the expression of DNA-repair gene Rad51.FoxM1 抑制通过下调 DNA 修复基因 Rad51 的表达使耐替莫唑胺的胶质母细胞瘤细胞对替莫唑胺敏感。
Clin Cancer Res. 2012 Nov 1;18(21):5961-71. doi: 10.1158/1078-0432.CCR-12-0039. Epub 2012 Sep 12.
5
Computational exploration of FOXM1 inhibitors for glioblastoma: an integrated virtual screening and molecular dynamics simulation study.胶质母细胞瘤的FOXM1抑制剂的计算探索：一项综合虚拟筛选和分子动力学模拟研究
J Biomol Struct Dyn. 2025 Jul;43(10):5199-5217. doi: 10.1080/07391102.2024.2308772. Epub 2024 Feb 2.
6
Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma.人类肿瘤的免疫分析鉴定 CD73 为胶质母细胞瘤的组合靶标。
Nat Med. 2020 Jan;26(1):39-46. doi: 10.1038/s41591-019-0694-x. Epub 2019 Dec 23.
7
Dual Suppressive Effect of miR-34a on the FOXM1/eEF2-Kinase Axis Regulates Triple-Negative Breast Cancer Growth and Invasion.miR-34a 对 FOXM1/eEF2 激酶轴的双重抑制作用调控三阴性乳腺癌的生长和侵袭。
Clin Cancer Res. 2018 Sep 1;24(17):4225-4241. doi: 10.1158/1078-0432.CCR-17-1959. Epub 2018 May 10.
8
A systematic review of overall survival in pediatric primary glioblastoma multiforme of the spinal cord.脊髓原发性多形性胶质母细胞瘤患儿总生存期的系统评价。
J Neurosurg Pediatr. 2017 Feb;19(2):239-248. doi: 10.3171/2016.8.PEDS1631. Epub 2016 Nov 4.
9
Licochalcone A suppresses pancreatic ductal adenocarcinoma progression by targeting eEF2K-mediated pyroptosis.甘草查尔酮A通过靶向eEF2K介导的细胞焦亡抑制胰腺导管腺癌进展。
Front Pharmacol. 2025 Jun 11;16:1595686. doi: 10.3389/fphar.2025.1595686. eCollection 2025.
10
A novel approach to enhance glioblastoma multiforme treatment efficacy: non-coding RNA targeted therapy and adjuvant approaches.一种提高多形性胶质母细胞瘤治疗效果的新方法：非编码RNA靶向治疗及辅助方法。
Clin Epigenetics. 2025 Jun 21;17(1):108. doi: 10.1186/s13148-025-01900-5.

本文引用的文献

1
Inhibition of FOXM1 Leads to Suppression of Cell Proliferation, Migration, and Invasion Through AXL/eEF2 Kinase Signaling and Induces Apoptosis and Ferroptosis in GBM Cells.抑制FOXM1通过AXL/eEF2激酶信号传导导致细胞增殖、迁移和侵袭受到抑制，并诱导胶质母细胞瘤细胞凋亡和铁死亡。
Int J Mol Sci. 2025 Jul 15;26(14):6792. doi: 10.3390/ijms26146792.
2
Recent discovery and development of AXL inhibitors as antitumor agents.AXL 抑制剂作为抗肿瘤药物的最新发现和进展。
Eur J Med Chem. 2024 Jun 5;272:116475. doi: 10.1016/j.ejmech.2024.116475. Epub 2024 May 3.
3
Deciphering the link: ferroptosis and its role in glioma.解析关联：铁死亡及其在神经胶质瘤中的作用。
Front Immunol. 2024 Jan 23;15:1346585. doi: 10.3389/fimmu.2024.1346585. eCollection 2024.
4
Regulation of the Receptor Tyrosine Kinase AXL in Response to Therapy and Its Role in Therapy Resistance in Glioblastoma.受体酪氨酸激酶 AXL 的调控及其在胶质母细胞瘤治疗抵抗中的作用。
Int J Mol Sci. 2022 Jan 17;23(2):982. doi: 10.3390/ijms23020982.
5
Eukaryotic elongation factor-2 kinase (eEF2K) signaling in tumor and microenvironment as a novel molecular target.真核延伸因子-2 激酶 (eEF2K) 在肿瘤和微环境中的信号转导作为一种新的分子靶点。
J Mol Med (Berl). 2020 Jun;98(6):775-787. doi: 10.1007/s00109-020-01917-8. Epub 2020 May 7.
6
Inhibiting receptor tyrosine kinase AXL with small molecule inhibitor BMS-777607 reduces glioblastoma growth, migration, and invasion in vitro and in vivo.用小分子抑制剂BMS-777607抑制受体酪氨酸激酶AXL可降低胶质母细胞瘤在体外和体内的生长、迁移及侵袭能力。
Oncotarget. 2016 Mar 1;7(9):9876-89. doi: 10.18632/oncotarget.7130.
7
Glioblastoma multiforme formation and EMT: role of FoxM1 transcription factor.多形性胶质母细胞瘤的形成与上皮-间质转化：FoxM1转录因子的作用
Curr Pharm Des. 2015;21(10):1268-71. doi: 10.2174/1381612821666141211115949.
8
Elongation factor-2 kinase regulates autophagy in human glioblastoma cells.延伸因子2激酶调节人胶质母细胞瘤细胞中的自噬。
Cancer Res. 2006 Mar 15;66(6):3015-23. doi: 10.1158/0008-5472.CAN-05-1554.

FOXM1-AXL/eEF2K靶向：一种针对多形性胶质母细胞瘤的有前景的治疗策略。

FOXM1-AXL/eEF2K Targeting: A Promising Treatment Strategy for Glioblastoma Multiforme Tumors.

作者信息

Piperi Christina, Papavassiliou Kostas A, Papavassiliou Athanasios G

机构信息

Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

First University Department of Respiratory Medicine, 'Sotiria' Chest Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

出版信息

Cancers (Basel). 2025 Aug 15;17(16):2662. doi: 10.3390/cancers17162662.

DOI:10.3390/cancers17162662
PMID:40867299
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12384737/
Abstract

In a recent study, Biltekin and colleagues [...].

摘要

在最近的一项研究中，比尔泰金及其同事们[...]。