Jin Soll, Kim Jae-Goo, Kim Hye Jin, Kim Ji Young, Kim Sang Hoon, Kang Hee Cheol, Kim Mi Jung
Human & Microbiome Communicating Laboratory, GFC Life Science Co., Ltd., Hwaseong 18471, Republic of Korea.
Department of Biology, Kyung Hee University, Seoul 02447, Republic of Korea.
Biomolecules. 2025 Aug 1;15(8):1108. doi: 10.3390/biom15081108.
Wound healing is a complex and dynamic process involving several stages of tissue repair. This study has shown that extracellular vesicles (EVs) derived from the callus of L. and their associated microRNAs (miRNAs) possess significant wound healing activities. In human fibroblasts, EVs from L. stimulated wound healing and upregulated collagen gene expression. The EVs also decreased inflammation levels in human keratinocytes, supporting wound healing. Among the miRNAs identified, miR408, one of the abundant miRNAs in the EVs, also showed similar wound healing efficacy. These findings suggest that both EVs and miR408 from the callus of L. play a pivotal role in promoting wound healing. Additionally, this study shows that the regulation of miRNAs between different kingdoms can be achieved and suggests a new direction for the utilization of plant-derived components.
伤口愈合是一个复杂且动态的过程，涉及组织修复的多个阶段。本研究表明，来源于L.愈伤组织的细胞外囊泡（EVs）及其相关的微小RNA（miRNAs）具有显著的伤口愈合活性。在人成纤维细胞中，来自L.的EVs刺激伤口愈合并上调胶原蛋白基因表达。这些EVs还降低了人角质形成细胞中的炎症水平，从而促进伤口愈合。在鉴定出的miRNAs中，miR408是EVs中含量丰富的miRNAs之一，也显示出类似的伤口愈合功效。这些发现表明，来自L.愈伤组织的EVs和miR408在促进伤口愈合中都起着关键作用。此外，本研究表明不同生物界之间的miRNAs调控是可以实现的，并为植物来源成分的利用提出了新方向。
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