Zeng Tianjiao, Chen Lusi, Yoshitomi Toru, Kawazoe Naoki, Yang Yingnan, Chen Guoping
Research Center for Macromolecules and Biomaterials, National Institute for Materials Science, Namiki 1-1, Tsukuba 305-0044, Ibaraki, Japan.
Graduate School of Science and Technology, University of Tsukuba, Tsukuba 305-8577, Ibaraki, Japan.
Biomedicines. 2025 Aug 4;13(8):1899. doi: 10.3390/biomedicines13081899.
Tumor treatments have substantially advanced through various approaches, including chemotherapy, radiotherapy, immunotherapy, and gene therapy. However, efficient treatment necessitates overcoming physiological barriers that impede the delivery of therapeutic agents to target sites. Drug delivery systems (DDSs) are a prominent research area, particularly in tumor therapy. This review provides a comprehensive overview of hydrogel-based DDSs for tumor treatment, focusing on the strategies and designs of DDSs based on the unique pathophysiological characteristics of tumors. The design and preparation of hydrogel systems for DDSs are summarized and highlighted. The challenges and opportunities for translating hydrogel-based DDSs into clinical applications are discussed.
肿瘤治疗已经通过多种方法取得了显著进展，包括化疗、放疗、免疫疗法和基因疗法。然而，有效的治疗需要克服阻碍治疗药物输送到靶点的生理屏障。药物递送系统（DDSs）是一个突出的研究领域，特别是在肿瘤治疗方面。本综述全面概述了用于肿瘤治疗的水凝胶基DDSs，重点介绍了基于肿瘤独特病理生理特征的DDSs策略和设计。总结并强调了用于DDSs的水凝胶系统的设计和制备。讨论了将水凝胶基DDSs转化为临床应用所面临的挑战和机遇。
