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用于抗肿瘤药物递送的水凝胶的研究策略与方法

Research Strategies and Methods of Hydrogels for Antitumor Drug Delivery.

作者信息

Zeng Tianjiao, Chen Lusi, Yoshitomi Toru, Kawazoe Naoki, Yang Yingnan, Chen Guoping

机构信息

Research Center for Macromolecules and Biomaterials, National Institute for Materials Science, Namiki 1-1, Tsukuba 305-0044, Ibaraki, Japan.

Graduate School of Science and Technology, University of Tsukuba, Tsukuba 305-8577, Ibaraki, Japan.

出版信息

Biomedicines. 2025 Aug 4;13(8):1899. doi: 10.3390/biomedicines13081899.

DOI:10.3390/biomedicines13081899
PMID:40868153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12383573/
Abstract

Tumor treatments have substantially advanced through various approaches, including chemotherapy, radiotherapy, immunotherapy, and gene therapy. However, efficient treatment necessitates overcoming physiological barriers that impede the delivery of therapeutic agents to target sites. Drug delivery systems (DDSs) are a prominent research area, particularly in tumor therapy. This review provides a comprehensive overview of hydrogel-based DDSs for tumor treatment, focusing on the strategies and designs of DDSs based on the unique pathophysiological characteristics of tumors. The design and preparation of hydrogel systems for DDSs are summarized and highlighted. The challenges and opportunities for translating hydrogel-based DDSs into clinical applications are discussed.

摘要

肿瘤治疗已经通过多种方法取得了显著进展，包括化疗、放疗、免疫疗法和基因疗法。然而，有效的治疗需要克服阻碍治疗药物输送到靶点的生理屏障。药物递送系统（DDSs）是一个突出的研究领域，特别是在肿瘤治疗方面。本综述全面概述了用于肿瘤治疗的水凝胶基DDSs，重点介绍了基于肿瘤独特病理生理特征的DDSs策略和设计。总结并强调了用于DDSs的水凝胶系统的设计和制备。讨论了将水凝胶基DDSs转化为临床应用所面临的挑战和机遇。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6931/12383573/7d7cd6a50cc9/biomedicines-13-01899-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6931/12383573/621ecf47e86f/biomedicines-13-01899-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6931/12383573/5f9ce46e316f/biomedicines-13-01899-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6931/12383573/3f129ab17666/biomedicines-13-01899-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6931/12383573/5c7dcc40749f/biomedicines-13-01899-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6931/12383573/7d7cd6a50cc9/biomedicines-13-01899-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6931/12383573/621ecf47e86f/biomedicines-13-01899-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6931/12383573/5f9ce46e316f/biomedicines-13-01899-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6931/12383573/3f129ab17666/biomedicines-13-01899-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6931/12383573/5c7dcc40749f/biomedicines-13-01899-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6931/12383573/7d7cd6a50cc9/biomedicines-13-01899-g005.jpg

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本文引用的文献

[1]
Biocompatible porous PAM/CNT nanocomposite hydrogel films for sustained drug delivery and cancer therapy.

Sci Rep. 2025-7-1

[2]
Hybrid NIR-responsive liposome/hydrogel platform mediating chemo-photothermal therapy of retinoblastoma enhanced by quercetin as an adjuvant.

Theranostics. 2025-3-10

[3]
Localized Cancer Treatment Using Thiol-Ene Hydrogels for Dual Drug Delivery.

Biomacromolecules. 2025-5-12

[4]
A novel approach for the co-delivery of 5-fluorouracil and everolimus for breast cancer combination therapy: stimuli-responsive chitosan hydrogel embedded with mesoporous silica nanoparticles.

J Transl Med. 2025-3-31

[5]
Chitosan-based hydrogels: A comprehensive review of transdermal drug delivery.

Int J Biol Macromol. 2025-4

[6]
The effect of microenvironmental viscosity on the emergence of colon cancer cell resistance to doxorubicin.

J Mater Chem B. 2025-2-5

[7]
Targeted and precise drug delivery using a glutathione-responsive ultra-short peptide-based injectable hydrogel as a breast cancer cure.

Mater Horiz. 2025-2-3

[8]
Scaffolds functionalized with matrix metalloproteinase-responsive release of miRNA for synergistic magnetic hyperthermia and sensitizing chemotherapy of drug-tolerant breast cancer.

Bioact Mater. 2024-10-19

[9]
Primary Chemoablation of Recurrent Low-Grade Intermediate-Risk Nonmuscle-Invasive Bladder Cancer With UGN-102: A Single-Arm, Open-Label, Phase 3 Trial (ENVISION).

J Urol. 2025-2

[10]
Effect of Hydrogel Stiffness on Chemoresistance of Breast Cancer Cells in 3D Culture.

Gels. 2024-3-17

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