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使用硫醇-烯水凝胶进行双药递送的局部癌症治疗

Localized Cancer Treatment Using Thiol-Ene Hydrogels for Dual Drug Delivery.

作者信息

Sathi Devi Lakshmi, Gigliobianco Maria Rosa, Gabrielli Serena, Agas Dimitrios, Sabbieti Maria Giovanna, Morelli Maria Beatrice, Amantini Consuelo, Casadidio Cristina, Di Martino Piera, Censi Roberta

机构信息

School of Pharmacy, ChIP Chemistry Interdisciplinary Project Research Centre, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, MC, Italy.

Department of Pharmacy, University of "G. D'Annunzio" Chieti and Pescara, Via dei Vestini 1, 66100 Chieti, CH, Italy.

出版信息

Biomacromolecules. 2025 May 12;26(5):3234-3254. doi: 10.1021/acs.biomac.5c00387. Epub 2025 Apr 8.

DOI:10.1021/acs.biomac.5c00387
PMID:40198273
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12076507/
Abstract

Combinatorial cancer therapy benefits from injectable hydrogels for localized, controlled drug delivery. This study presents a thiol-ene conjugated hydrogel formed by cross-linking thiol-modified hyaluronic acid (HASH) with vinyl sulfone-modified β-cyclodextrin (CDVS). Four formulations (23Gel-16, 23Gel-33, 99Gel-16, 99Gel-33) were synthesized by varying HASH molecular weight (23 or 99 kDa) and CDVS modification (16% or 33%). Rheological analysis confirmed enhanced viscoelasticity with increasing molecular weight and modification (99Gel-33 > 99Gel-16 > 23Gel-33 > 23Gel-16). The system enabled combinatorial delivery of doxorubicin (DOX) and carvacrol (CRV), exhibiting tumor-responsive degradation and tunable release. DOX release accelerated under tumor-mimicking conditions (100% in 46 h vs 58.7% in PBS), while CRV showed an initial burst followed by sustained release. The hydrogel promoted mesenchymal stem cell proliferation and effectively inhibited triple-negative breast cancer cells. This injectable, tumor-responsive hydrogel system offers a promising platform for minimally invasive, personalized cancer therapy.

摘要

组合癌症疗法受益于可注射水凝胶用于局部、可控药物递送。本研究展示了一种通过将硫醇修饰的透明质酸（HASH）与乙烯基砜修饰的β-环糊精（CDVS）交联形成的硫醇-烯共轭水凝胶。通过改变HASH分子量（23或99 kDa）和CDVS修饰（16%或33%）合成了四种配方（23Gel-16、23Gel-33、99Gel-16、99Gel-33）。流变学分析证实，随着分子量和修饰的增加，粘弹性增强（99Gel-33 > 99Gel-16 > 23Gel-33 > 23Gel-16）。该系统能够实现阿霉素（DOX）和香芹酚（CRV）的组合递送，表现出肿瘤响应性降解和可调节释放。在模拟肿瘤条件下，DOX释放加速（46小时内释放100%，而在PBS中为58.7%），而CRV显示出初始爆发后持续释放。水凝胶促进间充质干细胞增殖并有效抑制三阴性乳腺癌细胞。这种可注射的、肿瘤响应性水凝胶系统为微创、个性化癌症治疗提供了一个有前景的平台。

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J Transl Med. 2024 Sep 30;22(1):879. doi: 10.1186/s12967-024-05490-3.
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3
Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions.
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Gels. 2025 Jul 3;11(7):520. doi: 10.3390/gels11070520.
水凝胶在先进治疗应用中的潜力：当前的成就和未来的方向。
Signal Transduct Target Ther. 2024 Jul 1;9(1):166. doi: 10.1038/s41392-024-01852-x.
4
A comprehensive review on doxorubicin: mechanisms, toxicity, clinical trials, combination therapies and nanoformulations in breast cancer.关于阿霉素的全面综述：乳腺癌中的作用机制、毒性、临床试验、联合疗法及纳米制剂
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5
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Int J Biol Macromol. 2024 Jun;270(Pt 1):132275. doi: 10.1016/j.ijbiomac.2024.132275. Epub 2024 May 9.
6
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Int J Mol Sci. 2024 Apr 21;25(8):4547. doi: 10.3390/ijms25084547.
7
Multifunctionality of cyclodextrin-based polymeric nanoparticulate delivery systems for chemotherapeutics, combination therapy, and theranostics.基于环糊精的聚合物纳米粒给药系统的多功能性用于化疗、联合治疗和治疗学。
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8
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