血浆血小板反应蛋白-1与儿童慢性肾脏病蛋白尿事件的病因特异性关联

Plasma Thrombospondin-1 in Etiology-Specific Associations with Proteinuria Events in Pediatric Chronic Kidney Disease.

作者信息

Lu Pei-Chen, Liao Wei-Ting, Hsu Chien-Ning, Tain You-Lin, Chou Chia-An

机构信息

Division of Pediatric Nephrology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.

Department of Pediatrics, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 801, Taiwan.

出版信息

Children (Basel). 2025 Aug 21;12(8):1101. doi: 10.3390/children12081101.

DOI:10.3390/children12081101

PMID:40868552

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12384188/

Abstract

BACKGROUND

Thrombospondin-1 (TSP-1) is a matricellular protein involved in kidney fibrosis, potentially influencing the progression of proteinuria. However, its potential as a predictive biomarker for proteinuria events in children with chronic kidney disease (CKD), particularly across different etiological subgroups, such as congenital anomalies of the kidney and urinary tract (CAKUT) and non-CAKUT, has not been fully explored.

METHODS

In this prospective study of 60 children with CKD, we assessed baseline plasma TSP-1 and tracked proteinuria events over one year. Participants were stratified into CAKUT and non-CAKUT groups.

RESULTS

In total, 5 of 60 participants had proteinuria events. Plasma TSP-1 was significantly lower in patients with events (21.18 vs. 36.28 μg/mL, = 0.0364). In multivariable analysis, TSP-1 lost significance overall but remained predictive in the non-CAKUT subgroup (AUC = 0.79, = 0.064; OR = 0.93, = 0.028).

CONCLUSIONS

Plasma TSP-1 may serve as an etiology-specific biomarker for proteinuria events in pediatric CKD, particularly among non-CAKUT patients, and warrants further investigation for personalized risk assessment.

摘要

背景

血小板反应蛋白-1（TSP-1）是一种基质细胞蛋白，参与肾脏纤维化，可能影响蛋白尿的进展。然而，其作为慢性肾脏病（CKD）患儿蛋白尿事件预测生物标志物的潜力，尤其是在不同病因亚组中，如先天性肾脏和尿路畸形（CAKUT）和非CAKUT，尚未得到充分探索。

方法

在这项对60例CKD患儿的前瞻性研究中，我们评估了基线血浆TSP-1，并跟踪了一年中的蛋白尿事件。参与者被分为CAKUT组和非CAKUT组。

结果

60名参与者中共有5人发生蛋白尿事件。发生事件的患者血浆TSP-1显著降低（21.18对36.28μg/mL，P = 0.0364）。在多变量分析中，TSP-1总体上失去了显著性，但在非CAKUT亚组中仍具有预测性（AUC = 0.79，P = 0.064；OR = 0.93，P = 0.028）。