Hackel C, Beiguelman B
Int J Lepr Other Mycobact Dis. 1985 Dec;53(4):533-9.
A search for structural and numerical chromosomal aberrations was made on metaphases obtained by culturing in vitro skin fibroblasts of 16 leprosy patients (10 lepromatous, 2 borderline, and 4 tuberculoid cases) and 2 healthy individuals used as controls. The data were analyzed taking into account sex, age, race, form of leprosy, bacterial index, type of therapy, and age of the fibroblast cultures. Structural chromosomal aberrations are the only type of chromosomal abnormality that may be accepted as significantly increased in the skin fibroblasts of leprosy patients who are under treatment with dapsone alone or with combined therapy.
对16例麻风患者（10例瘤型、2例界线类和4例结核样型）及2名作为对照的健康个体的皮肤成纤维细胞进行体外培养，获得中期细胞，对其进行染色体结构和数目畸变检测。分析数据时考虑了性别、年龄、种族、麻风类型、细菌指数、治疗类型和成纤维细胞培养的年龄。染色体结构畸变是唯一一种在仅用氨苯砜治疗或联合治疗的麻风患者皮肤成纤维细胞中可被认为显著增加的染色体异常类型。
