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利用猪模型评估氦/氩产生的冷大气等离子体装置的安全性

Assessment of a Helium/Argon-Generated Cold Atmospheric Plasma Device's Safety Utilizing a Pig Model.

作者信息

Zhang Xin-Rui, Trinh Thuy-Tien Thi, Thuy Linh Le Thi, Giang Nguyen Ngan, Jin Yong-Xun, Lee Young-Hyun, Ahn Gun-Young, Goo Boncheol Leo, Jung Kyoung-Su, Hwang Hyun-Soo, Chien Pham Ngoc, Heo Chan-Yeong

机构信息

Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea.

Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

出版信息

Int J Mol Sci. 2025 Aug 14;26(16):7854. doi: 10.3390/ijms26167854.

DOI:10.3390/ijms26167854
PMID:40869175
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12386185/
Abstract

The PlazMagik device is a dual-gas cold atmospheric plasma (CAP) system that was developed and used for skin rejuvenation and inflammation treatment. However, preclinical evaluation and optimization of plasma parameters are crucial for guaranteeing safety. Therefore, this study was performed to evaluate the safety of the PlazMagik device under multiple parameters with different gas resources (helium (He) and argon (Ar) gases) on pig dorsal skin. After application of PlazMagik to the pig's dorsal skin, temperature and visual assessments were observed immediately and for up to 30 days. All clinical parameters, including body weight and blood serum biochemistry, along with histopathological analysis (H&E, MT, VB, NBTC staining), were monitored pre-application and at 1, 7, 15, and 30 days post-application of the plasma device. Our results confirmed the safety of the machine at low-output energy settings, which showed gentle skin exfoliation but no tissue damage, while high-output settings led to the skin erosion effect, then developing erythema and coagulation. Ar gas resulted in more significant heat production and pathological changes than He under identical conditions. These findings emphasize the importance of the preclinical evaluation of the energy settings and gas selection on optimizing CAP system performance for safe clinical applications and appropriate application purposes.

摘要

PlazMagik设备是一种双气体冷大气等离子体（CAP）系统，用于皮肤年轻化和炎症治疗。然而，临床前评估和等离子体参数的优化对于确保安全性至关重要。因此，本研究旨在评估PlazMagik设备在多种参数下，使用不同气体资源（氦气（He）和氩气（Ar））对猪背部皮肤的安全性。将PlazMagik应用于猪背部皮肤后，立即观察并持续30天观察温度和视觉评估。在等离子体设备应用前以及应用后1、7、15和30天，监测所有临床参数，包括体重和血清生化指标，以及组织病理学分析（苏木精-伊红染色、甲苯胺蓝染色、维多利亚蓝染色、硝酸银染色）。我们的结果证实了该设备在低输出能量设置下的安全性，表现为温和的皮肤剥脱但无组织损伤，而高输出设置则导致皮肤糜烂效应，随后出现红斑和凝血。在相同条件下，氩气比氦气产生的热量和病理变化更显著。这些发现强调了临床前评估能量设置和气体选择对于优化CAP系统性能以实现安全临床应用和适当应用目的的重要性。

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