Fotie Jean
Department of Chemistry and Physics, Southeastern Louisiana University, SLU 10878, Hammond, LA 70402, USA.
Int J Mol Sci. 2025 Aug 16;26(16):7918. doi: 10.3390/ijms26167918.
Tailored mesoporous silicate nanomaterials have attracted significant interest due to their exceptional surface properties, including high interfacial toughness, tunable thickness, customizable topology, optical transparency, and adjustable hydrophobicity. These characteristics enable them to exhibit a wide range of functional behaviors, such as antibacterial, anti-fouling, anti-fogging, lubricating, and abrasion-resistant properties, to name just a few. With recent advances in surface-modified nanosystems for bioengineering and biomedical applications, silica-based nanomaterials have emerged as promising candidates owing to their ease of surface functionalization, bioactivity, biocompatibility, biodegradability, and bioavailability. Consequently, they have been widely explored in various therapeutic contexts. This review provides a concise and concentrated summary of recent advances and applications of tailored mesoporous silicate nanomaterials in regenerative medicine and theranostics, with the primary focus being on how endogenous or exogenous triggers can be leveraged to achieve selective and precise delivery of various biomolecules and active therapeutics across diverse cellular environments, by harnessing the intrinsic properties of mesoporous silicate nanoparticles. This focus also guided the selection of specific examples provided to highlight their wide range of applications, with the report concluding with some perspectives and remaining challenges.
定制的介孔硅酸盐纳米材料因其优异的表面性质而备受关注，这些性质包括高界面韧性、可调节的厚度、可定制的拓扑结构、光学透明度和可调节的疏水性。这些特性使它们能够展现出广泛的功能行为，比如抗菌、防污、防雾、润滑和耐磨性能等等。随着用于生物工程和生物医学应用的表面改性纳米系统的最新进展，基于二氧化硅的纳米材料因其易于表面功能化、生物活性、生物相容性、生物可降解性和生物利用度而成为有前景的候选材料。因此，它们已在各种治疗环境中得到广泛探索。本综述简要而集中地总结了定制介孔硅酸盐纳米材料在再生医学和治疗诊断学中的最新进展及应用，主要关注如何利用介孔硅酸盐纳米颗粒的固有特性，通过内源性或外源性触发因素，在不同的细胞环境中实现各种生物分子和活性治疗剂的选择性和精确递送。这一重点也指导了所提供的具体示例的选择，以突出其广泛的应用，报告最后给出了一些观点和尚存的挑战。
