Cîmpianu Mihaela Elvira, Onișan Emilian, Sărac Viviana Maria, Sărac Ioan, Ganea Mariana, Octavia Gligor, Bâlici Ștefana, Nicula Gheorghe Zsolt, Domșa Elena Maria, Cîmpianu Teodora, Rusu Sergiu Ionica, Coman Horia George, Vică Matei Mihaela Laura, Siserman Costel Vasile
Department of Cellular and Molecular Biology, Iuliu Haṭieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
Department of Social Sciences, "1st December 1918" University of Alba Iulia, 510009 Alba Iulia, Romania.
Int J Mol Sci. 2025 Aug 20;26(16):8053. doi: 10.3390/ijms26168053.
Suicide, a major contributor to global mortality rates, especially among young patients, remains insufficiently integrated into public health initiatives despite notable progress in identifying its determinants. The prediction of suicidal behavior remains complex, often relying on subjective assessments rather than objective biomarkers. Single nucleotide polymorphisms (SNPs) such as rs110402 ( gene), rs3800373 ( gene), and rs2289656 ( gene) have been linked to physiological mechanisms involving stress response and activation of the hypothalamic-pituitary-adrenal (HPA) axis, which contributes to anxiety and stress regulation. This study aimed to assess stress-related gene polymorphisms in individuals with suicidal behavior compared to controls. According to our results, the presence of the A allele of rs2289656 was associated with a protective effect, while the GG genotype conferred a higher susceptibility to suicidal behaviors. Significant associations were observed between trauma and abuse history and the rs110402 polymorphism in gene, highlighting a protective role for the GG genotype and increased predisposition to stress-related psychiatric conditions and suicidal behavior for A allele carriers. No valid associations were found for rs3800373 in the gene, although suggestive trends related to depression and self-aggression were noted. Our findings underscore the need to identify reliable biomarkers associated with suicide risk, highlighting the importance of integrating hereditary and psychosocial data to better understand the underlying mechanisms and to support the development of effective early interventions.
自杀是全球死亡率的主要促成因素，在年轻患者中尤为突出。尽管在确定其决定因素方面取得了显著进展，但自杀在公共卫生举措中的整合仍不充分。自杀行为的预测仍然很复杂，通常依赖主观评估而非客观生物标志物。单核苷酸多态性（SNP），如rs110402（基因）、rs3800373（基因）和rs2289656（基因），已与涉及应激反应和下丘脑-垂体-肾上腺（HPA）轴激活的生理机制相关联，这有助于焦虑和应激调节。本研究旨在评估有自杀行为的个体与对照组相比的应激相关基因多态性。根据我们的结果，rs2289656的A等位基因的存在具有保护作用，而GG基因型赋予更高的自杀行为易感性。在创伤和虐待史与基因中的rs110402多态性之间观察到显著关联，突出了GG基因型的保护作用以及A等位基因携带者对应激相关精神疾病和自杀行为的易感性增加。在基因中的rs3800373未发现有效关联，尽管注意到与抑郁和自我攻击相关的提示性趋势。我们的研究结果强调需要识别与自杀风险相关的可靠生物标志物，突出了整合遗传和心理社会数据以更好地理解潜在机制并支持有效早期干预措施发展的重要性。
