Al Kharbooshi Jihad Yaqoob Ali, Al-Asmi Abdullah, Wesonga Ronald, Al Adawi Samir, Al-Fahdi Amal S S
Department of Clinical Neurological Sciences, Western University, London Health Sciences Center, London, ON N6A 3K7, Canada.
Neurology Unit, Department of Medicine, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat 123, Oman.
Int J Environ Res Public Health. 2025 Aug 7;22(8):1236. doi: 10.3390/ijerph22081236.
(1) Background: The COVID-19 pandemic presented unprecedented challenges for people with multiple sclerosis (PwMS) in Oman, necessitating targeted healthcare planning and patient support. This study aimed to investigate the impact of COVID-19 on MS management and disease course, incidence, and outcomes of COVID-19, psychosocial and mental health effects of the pandemic, and demographic and clinical predictors of the effects related to COVID-19 among Omani PwMS. (2) Methods: This cross-sectional study was conducted from January to April 2021. Adult (18-60 years) Omani PwMS completed a structured interview along with the Expanded Disability Status Scale (EDSS) and World Health Organization Well-being Index (WHO-5). Clinical data on relapses and disease-modifying therapies and adherence were analyzed. The data was statistically analyzed. (3) Results: Of 104 PwMS (73.1% female), 22.1% contracted COVID-19, with fatigue being the most reported symptom (87%). Female sex ( = 0.042), younger age (18-34 vs. 35-45 years; = 0.014), diagnosis of COVID-19 ( = 0.037), and low current mental well-being scores ( = 0.021) predicted greater COVID-19-related effects. (4) Conclusion: These findings highlight the need to study the mental resilience of this subgroup of PwMS and provide them with targeted support during crises.
(1) 背景：新冠疫情给阿曼的多发性硬化症患者（PwMS）带来了前所未有的挑战，因此需要有针对性的医疗规划和患者支持。本研究旨在调查新冠疫情对多发性硬化症管理及疾病进程的影响、新冠疫情的发病率和结局、疫情对心理社会和心理健康的影响，以及阿曼多发性硬化症患者中与新冠疫情相关影响的人口统计学和临床预测因素。(2) 方法：本横断面研究于2021年1月至4月进行。成年（18 - 60岁）阿曼多发性硬化症患者完成了一次结构化访谈，同时完成了扩展残疾状态量表（EDSS）和世界卫生组织幸福指数（WHO - 5）。分析了复发、疾病修饰治疗及依从性方面的临床数据。对数据进行了统计学分析。(3) 结果：在104名多发性硬化症患者（73.1%为女性）中，22.1%感染了新冠病毒，最常报告的症状是疲劳（87%）。女性（P = 0.042）、年龄较小（18 - 34岁与35 - 45岁相比；P = 0.014）、新冠病毒感染诊断（P = 0.037）以及当前心理健康得分较低（P = 0.021）预示着与新冠疫情相关的影响更大。(4) 结论：这些发现凸显了研究这一亚组多发性硬化症患者心理复原力的必要性，并在危机期间为他们提供有针对性的支持。
