Galluzzo Roberto Noya, Da Correggio Karine Souza, von Wangenheim Aldo, Callado Gustavo Yano, Werner Heron, Araujo Júnior Edward, Castro Pedro Teixeira, Calagna Glória, Onofre Alexandre Sherlley Casimiro
Division of Tocogynecology, University Hospital Polydoro Ernani of São Thiago, Federal University of Santa Catarina (UFSC), Florianópolis 88036-800, Brazil.
Brazilian Institute for Digital Convergence, Federal University of Santa Catarina (UFSC), Florianópolis 88040-900, Brazil.
Diagnostics (Basel). 2025 Aug 8;15(16):1989. doi: 10.3390/diagnostics15161989.
To investigate the association between prenatal ultrasonographic markers of macrossomia and C-peptide, a neonatal hyperinsulinemia marker, in pregnancies complicated by gestational diabetes mellitus (GDM), with a focus on fetal adipose tissue thickness, liver length, and interventricular septal thickness. : This prospective cohort study included 223 pregnant women followed from 28 to 36 weeks of gestation in two referral centers in Brazil. The GDM group and matched controls underwent serial ultrasound assessments of fetal biometry, including thigh, abdominal, and subscapular skinfolds, fetal liver length, and interventricular septum thickness. Neonatal hyperinsulinemia was assessed using umbilical cord C-peptide levels. Statistical analyses included -tests, chi-square tests, correlation analyses, and multivariate logistic regression. : Fetuses of mothers with GDM exhibited significantly greater abdominal [t(221) = -3.999, < 0.01] and subscapular [t(221) = -2.502, = 0.02] skinfolds, liver length [t(221) = -3.785, < 0.01], and interventricular septum [t(221) = -4.781, < 0.01] thickness. However, umbilical cord C-peptide levels did not differ significantly between groups [t(189) = -1.724, = 0.09]. Only weak correlations were found between fetal ultrasound markers and C-peptide levels. Among all parameters, subcutaneous tissue thickness showed the highest (ρ = 0.30), though still limited, predictive value. Fetuses of mothers with GDM demonstrated increased measures of liver length, subscapular adiposity, and interventricular septal thickness compared to controls. However, these prenatal biometric markers showed weak correlations with neonatal C-peptide levels.
为了研究巨大儿的产前超声标志物与C肽（一种新生儿高胰岛素血症标志物）之间的关联，该研究聚焦于妊娠合并妊娠期糖尿病（GDM）孕妇的胎儿脂肪组织厚度、肝脏长度和室间隔厚度。：这项前瞻性队列研究纳入了巴西两个转诊中心223名从妊娠28周到36周进行随访的孕妇。GDM组和匹配的对照组接受了胎儿生物测量的系列超声评估，包括大腿、腹部和肩胛下皮褶厚度、胎儿肝脏长度和室间隔厚度。使用脐带C肽水平评估新生儿高胰岛素血症。统计分析包括t检验、卡方检验、相关性分析和多因素逻辑回归。：GDM母亲的胎儿表现出明显更大的腹部皮褶[t(221) = -3.999, P < 0.01]、肩胛下皮褶[t(221) = -2.502, P = 0.02]、肝脏长度[t(221) = -3.785, P < 0.01]和室间隔厚度[t(221) = -4.781, P < 0.01]。然而，两组之间的脐带C肽水平没有显著差异[t(189) = -1.724, P = 0.09]。胎儿超声标志物与C肽水平之间仅发现微弱的相关性。在所有参数中，皮下组织厚度显示出最高（ρ = 0.30），但仍然有限的预测价值。与对照组相比，GDM母亲的胎儿肝脏长度、肩胛下脂肪和室间隔厚度测量值增加。然而，这些产前生物测量标志物与新生儿C肽水平显示出微弱的相关性。
