(), a widespread gastric pathogen, has long been studied for its role in upper gastrointestinal disorders. While its involvement in gastritis, peptic ulcer disease, and gastric cancer is well established, its impact on esophageal diseases remains an area of ongoing investigation. Nevertheless, some data indicate that may be involved in the pathogenesis of gastroesophageal reflux disease-Barrett's esophagus-esophageal adenocarcinoma sequence. Similarly, the -related mast cell activation-an essential immunological event-may also play a crucial role in the progression from gastroesophageal reflux disease to Barrett's esophagus and esophageal adenocarcinoma. The underlying mechanisms include immune modulation, cytokine cascades, and microbial interactions that collectively shape the esophageal microenvironment. This review provides an in-depth analysis of these pathways, highlighting the potential role of -induced, mast cell-driven inflammation in esophageal disease progression and discussing emerging therapeutic strategies.