García-Tercero Elisa, Villalon Rubio Daniela, Belenguer-Varea Ángel, Cunha-Pérez Cristina, Viña José, Tarazona-Santabalbina Francisco José
Geriatric Medicine Department, Hospital Universitario de la Ribera, 46600 Alzira, Spain.
School of Doctorate, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain.
Nutrients. 2025 Aug 12;17(16):2616. doi: 10.3390/nu17162616.
This study addresses the prevalence and outcomes of sarcopenic diabetes among older adults hospitalized for hip fractures, highlighting its association with nutritional status, frailty, in-hospital outcomes, and mortality. With the global incidence of hip fractures anticipated to rise significantly, understanding these associations is crucial, especially considering the higher prevalence of sarcopenia in diabetic patients, which exacerbates outcomes.
An observational, unicentric case-control study nested within a real-world data cohort was conducted. It included 2631 older adults (aged ≥ 70 years) hospitalized for hip fractures at the Hospital Universitario de la Ribera, Spain, from 2014 to 2021. Diabetic patients were classified as cases, and non-diabetic patients served as controls. The study examined demographic variables, comorbidities, nutritional status, geriatric syndromes, and mortality, using the SARC-F questionnaire for sarcopenia screening.
The study found that cases (diabetic patients) presented with higher comorbidities, longer hospital stays, and a higher prevalence of sarcopenia, significantly impacting in-hospital and long-term mortality rates. The prevalence of possible sarcopenia was notably higher at 61.5% among diabetic patients. Sarcopenia was strongly correlated with worse functional outcomes and higher mortality.
Sarcopenic diabetes significantly increases the risk of adverse outcomes and mortality in older adults with hip fractures. The findings underscore the importance of routine screening for diabetes and sarcopenia in this patient population to mitigate risks and improve rehabilitation outcomes.
本研究探讨了因髋部骨折住院的老年人中肌肉减少性糖尿病的患病率及预后情况，强调了其与营养状况、衰弱、住院结局和死亡率的关联。鉴于全球髋部骨折发病率预计将显著上升，了解这些关联至关重要，尤其是考虑到糖尿病患者中肌肉减少症的患病率较高，这会使预后恶化。
开展了一项嵌套于真实世界数据队列中的观察性单中心病例对照研究。研究纳入了2014年至2021年期间在西班牙里韦拉大学医院因髋部骨折住院的2631名老年人（年龄≥70岁）。糖尿病患者被归类为病例组，非糖尿病患者作为对照组。该研究使用SARC-F问卷进行肌肉减少症筛查，调查了人口统计学变量、合并症、营养状况、老年综合征和死亡率。
研究发现，病例组（糖尿病患者）合并症更多、住院时间更长，肌肉减少症的患病率更高，这对住院和长期死亡率有显著影响。糖尿病患者中可能存在肌肉减少症的患病率显著更高，为61.5%。肌肉减少症与更差的功能结局和更高的死亡率密切相关。
肌肉减少性糖尿病显著增加了髋部骨折老年人出现不良结局和死亡的风险。研究结果强调了对该患者群体常规筛查糖尿病和肌肉减少症以降低风险和改善康复结局的重要性。
