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Estimation of the blood-plasma concentration ratio of diazepam in the rat.

作者信息

Klotz U

出版信息

J Pharmacokinet Biopharm. 1985 Jun;13(3):347-8. doi: 10.1007/BF01065659.

DOI:10.1007/BF01065659
PMID:4087167
Abstract
摘要

相似文献

1
Estimation of the blood-plasma concentration ratio of diazepam in the rat.大鼠体内地西泮血浆浓度比的测定。
J Pharmacokinet Biopharm. 1985 Jun;13(3):347-8. doi: 10.1007/BF01065659.
2
On the interaction of diazepam with human, rat and mouse plasma proteins and erythrocytes.关于地西泮与人、大鼠和小鼠血浆蛋白及红细胞的相互作用。
Biochem Pharmacol. 1982 Apr 1;31(7):1455-8. doi: 10.1016/0006-2952(82)90046-6.
3
[The pharmacokinetic and pharmacodynamic characteristics of diazepam in different populations of rats].
Farmakol Toksikol. 1991 Jan-Feb;54(1):46-9.
4
Pharmacokinetics of diazepam in the rat: influence of an experimentally induced hepatic injury.
Eur J Drug Metab Pharmacokinet. 1991;Spec No 3:94-101.
5
Effect of plasma protein binding on the uptake of methadone and diazepam in the isolated perfused rat lung.
Drug Metab Dispos. 1984 Sep-Oct;12(5):536-42.
6
Aging: changes in distribution of diazepam and metabolites in the rat.衰老：大鼠体内地西泮及其代谢物分布的变化
Drug Metab Dispos. 1986 May-Jun;14(3):299-302.
7
Tissue distribution of 14C-diazepam and its metabolites in rats.14C-地西泮及其代谢产物在大鼠体内的组织分布
Drug Metab Dispos. 1982 Nov-Dec;10(6):676-9.
8
Effect of the anticonvulsant denzimol on the disposition of diazepam in the rat.
J Pharm Pharmacol. 1986 Jun;38(6):469-72. doi: 10.1111/j.2042-7158.1986.tb04613.x.
9
Development of tolerance to the anticonvulsant effect of diazepam in amygdala-kindled rats.
Exp Neurol. 1985 Nov;90(2):373-84. doi: 10.1016/0014-4886(85)90026-3.
10
Influence of the composition of rat central lymph on the pharmacokinetics (the steady state during infusion, bioavailability, absorption) of diazepam, studied in the blood and lymph.
Physiol Bohemoslov. 1990;39(5):403-8.

引用本文的文献

1
Correlation of unbound plasma clearances of fifteen extensively metabolized drugs between humans and rats.
Pharm Res. 1988 Oct;5(10):668-72. doi: 10.1023/a:1015935206569.
2
Pharmacokinetic-pharmacodynamic modelling of the anticonvulsant effect of oxazepam in individual rats.奥沙西泮对个体大鼠抗惊厥作用的药代动力学-药效学建模
Br J Pharmacol. 1990 Jan;99(1):53-8. doi: 10.1111/j.1476-5381.1990.tb14653.x.
3
Extent and variability of the first-pass elimination of adinazolam mesylate in healthy male volunteers.
Pharm Res. 1991 Feb;8(2):162-7. doi: 10.1023/a:1015875516834.

本文引用的文献

1
Prediction of diazepam disposition in the rat and man by a physiologically based pharmacokinetic model.基于生理的药代动力学模型对大鼠和人体内地西泮处置的预测。
J Pharmacokinet Biopharm. 1983 Dec;11(6):577-93. doi: 10.1007/BF01059058.
2
Diazepam metabolism during chronic medication unbound fraction in plasma, erythrocytes and urine.长期用药期间地西泮在血浆、红细胞和尿液中的代谢及游离分数
J Chromatogr. 1973 Jan 3;75(1):55-78. doi: 10.1016/s0021-9673(01)83413-0.
3
The effects of age and liver disease on the disposition and elimination of diazepam in adult man.
年龄和肝脏疾病对成年男性体内地西泮处置与消除的影响。
J Clin Invest. 1975 Feb;55(2):347-59. doi: 10.1172/JCI107938.
4
Pharmacokinetics and plasma binding of diazepam in man, dog, rabbit, guinea pig and rat.地西泮在人、狗、兔、豚鼠和大鼠体内的药代动力学及血浆结合情况。
J Pharmacol Exp Ther. 1976 Oct;199(1):67-73.