口服花青素补充剂对体外神经发生、海马体依赖性认知及血液中痴呆生物标志物的影响：一项针对有痴呆风险的老年人进行的为期24周的随机对照试验（ACID）的结果
Effects of Oral Anthocyanin Supplementation on In Vitro Neurogenesis, Hippocampus-Dependent Cognition, and Blood-Based Dementia Biomarkers: Results from a 24-Week Randomized Controlled Trial in Older Adults At Risk for Dementia (ACID).
作者信息
de Lucia Chiara, Tovar-Rios Diego Alejandro, Khalifa Khadija, Kvernberg Silje Meihack, Pola Ilaria, Bergland Anne Katrine, Maple-Grødem Jodi, Siow Richard, Ashton Nicholas, Ballard Clive, Thuret Sandrine, Aarsland Dag
机构信息
Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Armauer Hansens vei 30, 4011 Stavanger, Norway.
Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Memory Lane, London S5 9NU, UK.
出版信息
Nutrients. 2025 Aug 19;17(16):2680. doi: 10.3390/nu17162680.
BACKGROUND
Identifying compounds with neuroprotective properties that target the neurogenic process will have a considerable impact on dementia prevention.
METHODS
This is a secondary analysis of a 24-week randomised, double-blind, placebo-controlled anthocyanin supplementation trial in 181 participants. Using blood-derived serum collected during this trial, we treated hippocampal progenitor cells and analysed the ensuing cellular changes in the context of the participant's clinical and blood-based biomarker data.
RESULTS
We show that anthocyanin supplementation impacts hippocampal progenitor cells and that this can impact hippocampal-dependent cognition. We also show for the first time that blood-based dementia biomarkers correlate with human in vitro neurogenesis markers.
CONCLUSIONS
Our data demonstrates moderator effects of BMI and ApoE4 carrier status and supports the need for more individualised trials. Further studies are warranted to explore the mechanism of action of anthocyanins and the use of blood-based biomarkers for clinical trial enrichment, trial individualization, and therapy development.
TRIAL REGISTRATION
NCT03419039; date first registered: 15/01/2018.
背景
鉴定具有针对神经发生过程的神经保护特性的化合物，将对痴呆症预防产生重大影响。
方法
这是一项对181名参与者进行的为期24周的随机、双盲、安慰剂对照花青素补充试验的二次分析。利用该试验期间采集的血液来源血清，我们处理了海马祖细胞，并结合参与者的临床和血液生物标志物数据分析了随后的细胞变化。
结果
我们发现补充花青素会影响海马祖细胞，且这可能会影响依赖海马的认知。我们还首次表明，基于血液的痴呆生物标志物与人类体外神经发生标志物相关。
结论
我们的数据证明了体重指数（BMI）和ApoE4携带者状态的调节作用，并支持进行更具个性化试验的必要性。有必要进一步开展研究，以探索花青素的作用机制，以及利用基于血液的生物标志物进行临床试验富集、试验个体化和治疗开发。
试验注册
NCT03419039；首次注册日期：2018年1月15日。
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