Bugingo Collins, Infantino Alessandro, Okello Paul, Perez-Hernandez Oscar, Petrović Kristina, Turatsinze Andéole Niyongabo, Moparthi Swarnalatha
Crop and Soil Science Department, Oregon State University, Corvallis, OR 97331, USA.
School of Integrative Plant Science, Horticulture Department, Cornell Agritech, Cornell University, Geneva, NY 14456, USA.
Pathogens. 2025 Aug 1;14(8):762. doi: 10.3390/pathogens14080762.
The genus includes some of the most economically and ecologically impactful fungal pathogens affecting global agriculture and human health. Over the past 15 years, rapid advances in molecular biology, genomics, and diagnostic technologies have reshaped our understanding of taxonomy, host-pathogen dynamics, mycotoxin biosynthesis, and disease management. This review synthesizes key developments in these areas, focusing on agriculturally important species complexes such as the species complex (FOSC), species complex (FGSC), and a discussion on emerging lineages such as . We explore recent shifts in species delimitation, functional genomics, and the molecular architecture of pathogenicity. In addition, we examine the global burden of -induced mycotoxins by examining their prevalence in three of the world's most widely consumed staple crops: maize, wheat, and rice. Last, we also evaluate contemporary management strategies, including molecular diagnostics, host resistance, and integrated disease control, positioning this review as a roadmap for future research and practical solutions in Fusarium-related disease and mycotoxin management. By weaving together morphological insights and cutting-edge multi-omics tools, this review captures the transition into a new era of Fusarium research where integrated, high-resolution approaches are transforming diagnosis, classification, and management.
该属包括一些对全球农业和人类健康具有最重大经济和生态影响的真菌病原体。在过去15年中，分子生物学、基因组学和诊断技术的快速发展重塑了我们对分类学、宿主-病原体动态、霉菌毒素生物合成和疾病管理的理解。本综述综合了这些领域的关键进展，重点关注农业上重要的物种复合体，如物种复合体（FOSC）、物种复合体（FGSC），并讨论了新兴谱系，如。我们探讨了物种界定、功能基因组学和致病性分子结构方面的最新变化。此外，我们通过研究霉菌毒素在世界上消费最广泛的三种主食作物（玉米、小麦和水稻）中的流行情况，来审视由霉菌毒素引起的全球负担。最后，我们还评估了当代管理策略，包括分子诊断、宿主抗性和综合疾病控制，将本综述定位为镰刀菌相关疾病和霉菌毒素管理未来研究及实际解决方案的路线图。通过将形态学见解与前沿的多组学工具结合起来，本综述描绘了镰刀菌研究进入一个新时代的转变，在这个新时代，综合的高分辨率方法正在改变诊断、分类和管理。
