Mitea Gabriela, Schröder Verginica, Iancu Irina Mihaela
Department of Pharmacology, Faculty of Pharmacy, Ovidius University of Constanta, 900470 Constanta, Romania.
Department of Cellular and Molecular Biology, Faculty of Pharmacy, Ovidius University of Constanta, 900470 Constanta, Romania.
Pharmaceuticals (Basel). 2025 Jul 24;18(8):1098. doi: 10.3390/ph18081098.
Oral squamous cell carcinoma (OSCC) is one of the most serious forms of cancer in the world. The opportunities to decrease the mortality rate would lie in the possibility of earlier identification of this pathology, and at the same time, the immediate approach of anticancer therapy. Furthermore, new treatment strategies for OSCC are needed to improve existing therapeutic options. Bioactive compounds found in medicinal plants could be used to support these strategies. It is already known that they have an increased potential for action and a safety profile; therefore, they could improve the therapeutic effect of classical chemotherapeutic agents in combination therapies. : This research was based on an extensive review of recently published studies in scientific databases (PubMed, Scopus, and Web of Science). The selection criteria were based on experimental protocols investigating molecular mechanisms, synergistic actions with conventional anticancer agents, and novel formulation possibilities (e.g., nanoemulsions and mucoadhesive films) for the targeted delivery of bioactive compounds in OSCC. Particular attention was given to in vitro, in vivo, translational, and clinical studies that have proven therapeutic relevance. : Recent discoveries regarding the effect of bioactive compounds in the treatment of oral cancer were analyzed, with a view to integrating them into oncological practice for increasing therapeutic efficacy and reducing the occurrence of adverse reactions and treatment resistance. : Significant progress has been achieved in this review, allowing us to appreciate that the valorization of these bioactive compounds is emerging.
口腔鳞状细胞癌（OSCC）是世界上最严重的癌症形式之一。降低死亡率的机会在于更早发现这种疾病的可能性，同时在于抗癌治疗的即时实施。此外，需要新的OSCC治疗策略来改善现有的治疗选择。药用植物中发现的生物活性化合物可用于支持这些策略。已知它们具有增强的作用潜力和安全性；因此，它们可以在联合治疗中提高经典化疗药物的治疗效果。：本研究基于对科学数据库（PubMed、Scopus和Web of Science）中最近发表的研究进行的广泛综述。选择标准基于研究分子机制、与传统抗癌药物的协同作用以及生物活性化合物在OSCC中靶向递送的新制剂可能性（如纳米乳液和粘膜粘附膜）的实验方案。特别关注已证明具有治疗相关性的体外、体内、转化和临床研究。：分析了关于生物活性化合物在口腔癌治疗中作用的最新发现，以期将其纳入肿瘤学实践，提高治疗效果，减少不良反应的发生和治疗耐药性。：本综述取得了重大进展，使我们认识到这些生物活性化合物的价值正在显现。
