Ozdemir Kutahya Zeynep, Aslan Akyol Busra, Mamuk Selen, Piner Benli Petek, Gokbulut Cengiz
Department of Veterinary Pharmacology and Toxicology, Faculty of Ceyhan Veterinary Medicine, Cukurova University, Adana 01330, Türkiye.
Department of Veterinary Pharmacology and Toxicology, Institute of Health Sciences, Balikesir University, Balikesir 10145, Türkiye.
Vet Sci. 2025 Jul 23;12(8):686. doi: 10.3390/vetsci12080686.
This study aimed to investigate the effect of gender on the pharmacokinetics of meloxicam in goats following intravenous (IV, 0.5 mg/kg) and oral (PO, 1.0 mg/kg) administration. A crossover design was used with 12 clinically healthy Saanen goats (six females and six males). Plasma samples were collected up to 96 h post-administration and analyzed with an HPLC for meloxicam concentrations. Pharmacokinetic parameters were calculated and statistically compared between genders and administration routes. The results show that male goats exhibited significantly longer terminal half-life (T), a greater mean residence time (MRT), and higher systemic exposure (AUC) than females, particularly after oral administration. Oral bioavailability was calculated as 77.43% in females and 104.73% in males. These differences may be linked to gender-based variations in hepatic metabolism, enterohepatic recirculation, and the hormone-mediated modulation of cytochrome P450 activity. The findings are consistent with previous research demonstrating that gender can influence drug disposition through hormonal and enzymatic mechanisms. This study underscores the importance of considering gender as a biological variable in pharmacokinetic assessments of veterinary drugs, especially those used in food-producing animals, to optimize dosing strategies and ensure both therapeutic efficacy and food safety.
本研究旨在探讨性别对美洛昔康经静脉注射（IV，0.5mg/kg）和口服（PO，1.0mg/kg）给药后在山羊体内药代动力学的影响。采用交叉设计，选用12只临床健康的萨能山羊（6只雌性和6只雄性）。给药后长达96小时采集血浆样本，并用高效液相色谱法分析美洛昔康浓度。计算药代动力学参数，并在性别和给药途径之间进行统计学比较。结果表明，雄性山羊的末端半衰期（T）显著长于雌性，平均驻留时间（MRT）更长，全身暴露量（AUC）更高，尤其是在口服给药后。雌性的口服生物利用度计算为77.43%，雄性为104.73%。这些差异可能与肝脏代谢、肠肝循环以及细胞色素P450活性的激素介导调节中的性别差异有关。这些发现与先前的研究一致，表明性别可通过激素和酶机制影响药物处置。本研究强调了在兽药药代动力学评估中，尤其是用于食用动物的兽药，将性别作为生物学变量加以考虑的重要性，以优化给药策略并确保治疗效果和食品安全。
