Poto Remo, Marone Gianni, Ziegler Steven F, Varricchi Gilda
Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
Istituti Clinici Scientifici Maugeri-Scientific Institute for Research Hospitalization and Healthcare (IRCCS) Scientific Institute of Telese Terme, Benevento, Italy.
Front Immunol. 2025 Aug 12;16:1627235. doi: 10.3389/fimmu.2025.1627235. eCollection 2025.
Thymic stromal lymphopoietin (TSLP) is an alarmin cytokine possessing a plethora of pleiotropic properties. Human and mouse TSLP exerts their activity a heterodimeric complex composed of TSLP receptor (TSLPR) chain and IL-7Rα. TSLP is predominantly expressed by epithelial cells and keratinocytes but can also be produced by several immune cells and some cancers. TSLP activates a plethora of immune cells implicated in inflammation, angiogenesis and tumorigenesis. In addition to its role in barrier immunity, recent studies have a role for TSLP in cancer development. This includes both human hematologic cancers and several solid tumors (largely carcinomas). The role of TSLP in human and experimental cancers has been the focus of several studies, with somewhat contradictory findings. In this Review, we will highlight recent advances in TSLP immunobiology in the context of human and experimental cancers. We will also discuss recent findings demonstrating that an anti-TSLP monoclonal antibody (mAb) can exert a protective effect in a mouse model of colorectal cancer. The recent approval of an anti-TSLP mAb for asthma treatment also emphasizes the urgent need for additional research on the role of TSLP, a Janus cytokine, in tumorigenesis.
胸腺基质淋巴细胞生成素（TSLP）是一种警报素细胞因子，具有多种多效性特性。人和小鼠的TSLP通过由TSLP受体（TSLPR）链和IL-7Rα组成的异二聚体复合物发挥其活性。TSLP主要由上皮细胞和角质形成细胞表达，但也可由多种免疫细胞和一些癌症产生。TSLP可激活大量与炎症、血管生成和肿瘤发生相关的免疫细胞。除了其在屏障免疫中的作用外，最近的研究表明TSLP在癌症发展中也发挥作用。这包括人类血液系统癌症和几种实体瘤（主要是 carcinomas）。TSLP在人类和实验性癌症中的作用一直是多项研究的重点，结果有些相互矛盾。在本综述中，我们将重点介绍在人类和实验性癌症背景下TSLP免疫生物学的最新进展。我们还将讨论最近的研究结果，这些结果表明抗TSLP单克隆抗体（mAb）在结直肠癌小鼠模型中可发挥保护作用。抗TSLP mAb最近被批准用于哮喘治疗，这也强调了迫切需要对TSLP（一种两面神细胞因子）在肿瘤发生中的作用进行更多研究。
