Lin Yingying, Wang Yuqi, Zhang Yuning, Lu Yao, Chen Juan, Luo Yongting, He Jian, Luo Qingfeng, Quan Heng, Yu Weiru, Luo Yujia, Xue Peng, Xue Yi, Lin Xiaoya, Ding Rui, Chen Lining, Wang Yiran, Xia Zenghui, Zhao Liang, Zhang Hao, Wang Ran, Wang Qingyu, Wang Xifan, Su Jiaqi, Ren Fazheng, Lv Cong, Li Yixuan, Guo Huiyuan
College of Food Science and Nutritional Engineering China Agricultural University Beijing China.
Key Laboratory of Functional Dairy, Department of Nutrition and Health China Agricultural University Beijing China.
Exploration (Beijing). 2025 Jun 10;5(4):20240363. doi: 10.1002/EXP.20240363. eCollection 2025 Aug.
The role of CD8 T cells in the pathogenesis of ulcerative colitis (UC) remains unclear. Similarly, the posttranscriptional regulation of the highly heterogenic CD8 T cell populations and their effector function in IBD also remains poorly understood. Here, we find that and ) regulate T cell fate, and their expression is higher near damaged colon tissue in patients with IBD compared to controls. In mice, we find that suppresses the differentiation of CD8 T cells and the secretion of pro-inflammatory and chemotactic factors during severe colitis by inhibiting transcriptional pathways, including those involving the T cell receptor and JAK-STAT signaling. Furthermore, we identify , an inflammatory factor that drives immune response and the reshaping of CD8 T cell fate, as a potential target of the miRNAs. Finally, we show that delivery of miR-29 mimics to the colon of mice is sufficient to alleviate DSS-induced inflammation. Together, these data show that plays an important role in suppressing T cell overactivation during inflammatory diseases.
CD8 T细胞在溃疡性结肠炎（UC）发病机制中的作用仍不清楚。同样，高度异质性的CD8 T细胞群体的转录后调控及其在炎症性肠病（IBD）中的效应功能也仍未得到充分了解。在此，我们发现[具体内容缺失]和[具体内容缺失]调节T细胞命运，并且与对照组相比，它们在IBD患者受损结肠组织附近的表达更高。在小鼠中，我们发现[具体内容缺失]通过抑制转录途径，包括涉及T细胞受体和JAK-STAT信号传导的途径，在严重结肠炎期间抑制CD8 T细胞的分化以及促炎和趋化因子的分泌。此外，我们确定[具体内容缺失]，一种驱动免疫反应和CD8 T细胞命运重塑的炎症因子，为miRNA的潜在靶标。最后，我们表明将miR-29模拟物递送至小鼠结肠足以减轻右旋糖酐硫酸钠（DSS）诱导的炎症。总之，这些数据表明[具体内容缺失]在抑制炎症性疾病期间T细胞过度活化中起重要作用。
