Sarwar Haider, Tan Nicholas, Alryalat Saif Aldeen, Capitena Young Cara Elise, Seibold Leonard K, Kahook Malik Y
Department of Ophthalmology, University of Colorado School of Medicine, Sue Anschutz-Rodgers Eye Center, Aurora, CO, USA.
Clin Ophthalmol. 2025 Aug 22;19:2939-2943. doi: 10.2147/OPTH.S542095. eCollection 2025.
To compare the acute structural changes of standard endoscopic cyclophotocoagulation (ECP), a novel ECP device (Leos™), and transscleral cyclophotocoagulation (TCP) on the ciliary processes and surrounding structures in human cadaveric eyes using scanning electron microscopy (SEM).
Three human cadaveric eyes were treated with standard ECP, Leos ECP, or TCP. Untreated areas served as controls. Tissues were prepared for SEM to evaluate microarchitectural changes in the ciliary processes and adjacent structures.
SEM imaging revealed that both standard and Leos ECP resulted in blunting of the ciliary processes without injury to collateral tissues. In contrast, TCP-treated tissues showed significant structural disorganization extending to the iris and pars plana.
In this study, we demonstrate that both standard and novel Leos ECP techniques produce significantly less structural disruption to the ciliary processes compared to TCP. The Leos ECP system, with its enhanced imaging and automation features, may offer more clinical value through ease-of-use and improved consistency while still generating similar tissue effects to standard ECP. Additionally, these findings further validate the more targeted approach that ECP offers compared to TCP. However, no clinical outcomes were evaluated in this study, and further investigation is needed to determine how these findings translate to patient care.
使用扫描电子显微镜（SEM）比较标准内镜睫状体光凝术（ECP）、一种新型ECP设备（Leos™）和经巩膜睫状体光凝术（TCP）对人尸体眼睫状体及周围结构的急性结构变化。
三只人尸体眼分别接受标准ECP、Leos ECP或TCP治疗。未治疗区域作为对照。制备组织用于SEM，以评估睫状体及相邻结构的微观结构变化。
SEM成像显示，标准ECP和Leos ECP均导致睫状体变钝，且未损伤周围组织。相比之下，TCP治疗的组织显示出明显的结构紊乱，延伸至虹膜和平坦部。
在本研究中，我们证明与TCP相比，标准和新型Leos ECP技术对睫状体产生的结构破坏明显更少。Leos ECP系统具有增强的成像和自动化功能，通过易于使用和提高一致性可能提供更多临床价值，同时仍能产生与标准ECP相似的组织效应。此外，这些发现进一步验证了ECP与TCP相比更具针对性的方法。然而，本研究未评估临床结果，需要进一步研究以确定这些发现如何转化为患者护理。
