Yang Zheng, Zhai Shaobo, Liu Yang, Wu Yuchuan, He Tianming, Shi Xiaolu, Chu Shunli
Hospital of Stomatology, Jilin University, Changchun, Jilin, 130021, People's Republic of China.
Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun, Jilin, 130021, People's Republic of China.
Int J Nanomedicine. 2025 Aug 22;20:10151-10175. doi: 10.2147/IJN.S524115. eCollection 2025.
Sticky bone is a new type of composite biological material in the field of dental implantation and restoration in recent years, which is usually composed of Autologous Fibrin Glue (AFG) or injectable-platelet rich fibrin (i-PRF) is prepared in combination with different types of bone augmentation materials, such as granular or powdered bone substitutes, providing a solution for bone regeneration that integrates growth factor release with bone scaffold functionality. Its unique gel texture ensures precise adhesion at the site of bone defects and does not fall apart due to external forces. This property not only enhances the stability of the bone graft, but also accelerates the regeneration and healing of bone tissue by providing an ideal environment for cell attachment and proliferation. In addition, the bioactivity and plasticity of sticky bone allow it to demonstrate higher adaptability and surgical success when compared to conventional bone grafting methods. Its development potential in bone tissue engineering also opens up new directions for future clinical applications. Overall, sticky bone is becoming a key material for promoting bone regeneration and improving implant success due to its sticky bone, scaffolding function and ability to carry bioactive components. In this paper aims to review the composition, preparation methods, mechanisms of action, and specific applications of sticky bone in oral implantation and related fields.
粘性骨是近年来口腔种植与修复领域的一种新型复合生物材料，它通常由自体纤维蛋白胶（AFG）或可注射富血小板纤维蛋白（i-PRF）与不同类型的骨增量材料（如颗粒状或粉末状骨替代物）组合制备而成，为将生长因子释放与骨支架功能相结合的骨再生提供了一种解决方案。其独特的凝胶质地确保在骨缺损部位精确粘附，不会因外力而散开。这一特性不仅增强了骨移植的稳定性，还通过为细胞附着和增殖提供理想环境来加速骨组织的再生和愈合。此外，粘性骨的生物活性和可塑性使其与传统骨移植方法相比具有更高的适应性和手术成功率。其在骨组织工程中的发展潜力也为未来的临床应用开辟了新方向。总体而言，粘性骨因其粘性、支架功能以及携带生物活性成分的能力，正成为促进骨再生和提高种植成功率的关键材料。本文旨在综述粘性骨在口腔种植及相关领域的组成、制备方法、作用机制和具体应用。
