Sone Daichi, Shinagawa Shunichiro
Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan.
Front Aging Neurosci. 2025 Aug 12;17:1633309. doi: 10.3389/fnagi.2025.1633309. eCollection 2025.
The biological basis of neuropsychiatric symptoms (NPS) in individuals who have dementia is poorly understood, despite the significant burden on patients, caregivers, and communities. Recent neuroimaging advances have provided reliable and less-invasive methods to investigate human brains . However, compared to the significant progress that has been made in the fields of diagnostic values and cognitive symptoms in dementia, the neuroimaging findings of NPS are less consistent, particularly in terms of the affected brain regions. This discrepancy may be due to differences in neuroimaging modalities or analytical methods, the fact that NPS can change over time, and/or the subjective nature of NPS assessments. In this narrative review, we summarize the extant literature on neuroimaging findings of NPS in dementia. We also discuss both the controversies and potential solutions to overcome the current problems.
尽管神经精神症状（NPS）给患者、照料者和社区带来了沉重负担，但对于患有痴呆症个体的NPS生物学基础仍知之甚少。最近的神经影像学进展提供了可靠且侵入性较小的方法来研究人类大脑。然而，与痴呆症诊断价值和认知症状领域取得的显著进展相比，NPS的神经影像学发现不太一致，特别是在受影响的脑区方面。这种差异可能是由于神经影像学模式或分析方法的不同、NPS会随时间变化这一事实，和/或NPS评估的主观性。在这篇叙述性综述中，我们总结了关于痴呆症中NPS神经影像学发现的现有文献。我们还讨论了争议以及克服当前问题的潜在解决方案。
