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伏隔核的雌激素调节作为理解绝经相关代谢功能障碍的切入点。

Estrogen regulation of the nucleus accumbens as a gateway to understanding menopause associated metabolic dysfunction.

作者信息

Rosenfeld Cheryl S, Vieira-Potter Victoria J

机构信息

Biomedical Sciences. University of Missouri, Columbia, MO, USA.

MU Institute for Data Science and Informatics, University of Missouri, Columbia, MO, USA.

出版信息

NPJ Womens Health. 2025;3. doi: 10.1038/s44294-025-00071-1. Epub 2025 Apr 23.

DOI:10.1038/s44294-025-00071-1
PMID:40874093
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12380378/
Abstract

The nucleus accumbens (NAc) may be a link between metabolic and behavioral changes due to menopause. Loss of estrogen (E2) activation in the NAc might cause reduced physical activity and adipose tissue dysfunction. We review potential mechanisms by which NAc might communicate with adipose tissue and how menopause may impact this pathway. A better understanding of the NAc-adipose tissue axis will pave the way for improved treatments in menopausal women.

摘要

伏隔核（NAc）可能是更年期导致的代谢和行为变化之间的一个联系。伏隔核中雌激素（E2）激活的丧失可能会导致身体活动减少和脂肪组织功能障碍。我们综述了伏隔核可能与脂肪组织沟通的潜在机制，以及更年期可能如何影响这一途径。更好地理解伏隔核-脂肪组织轴将为改善更年期女性的治疗方法铺平道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ed/12380378/56fdb9bbed18/nihms-2089953-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ed/12380378/c36329fc0b7a/nihms-2089953-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ed/12380378/4c3808674bb3/nihms-2089953-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ed/12380378/56fdb9bbed18/nihms-2089953-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ed/12380378/c36329fc0b7a/nihms-2089953-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ed/12380378/4c3808674bb3/nihms-2089953-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4ed/12380378/56fdb9bbed18/nihms-2089953-f0003.jpg

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本文引用的文献

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Eur J Neurosci. 2024 Sep;60(5):4937-4953. doi: 10.1111/ejn.16477. Epub 2024 Jul 30.
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Exosome Therapy: A Novel Approach for Enhancing Estrogen Levels in Perimenopause.外泌体治疗：改善围绝经期雌激素水平的新方法。
Int J Mol Sci. 2024 Jun 27;25(13):7075. doi: 10.3390/ijms25137075.
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Estrogen deficiency reduces maximal running capacity and affects serotonin levels differently in the hippocampus and nucleus accumbens in response to acute exercise.
雌激素缺乏会降低最大跑步能力，并在急性运动时，对海马体和伏隔核中的血清素水平产生不同影响。
Front Neurosci. 2024 Jun 25;18:1399229. doi: 10.3389/fnins.2024.1399229. eCollection 2024.
4
Estrogen deficiency affects synchronized neural connectivity in the olfactory bulb-nucleus accumbens circuit: A local field potential study in ovariectomized mouse model.雌激素缺乏影响嗅球-伏隔核回路中同步的神经连接：在去卵巢小鼠模型中的局部场电位研究。
Horm Behav. 2024 Aug;164:105587. doi: 10.1016/j.yhbeh.2024.105587. Epub 2024 Jun 20.
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