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一种在……中产生盐浓度记忆依赖性趋化作用的神经网络模型。 （原句不完整，推测补充完整后的译文）

A neural network model that generates salt concentration memory-dependent chemotaxis in .

作者信息

Hironaka Masakatsu, Sumi Tomonari

机构信息

Department of Chemistry, Faculty of Science, Okayama University, Okayama, Japan.

Research Institute for Interdisciplinary Science, Okayama University, Okayama, Japan.

出版信息

Elife. 2025 Aug 28;14:RP104456. doi: 10.7554/eLife.104456.

DOI:10.7554/eLife.104456
PMID:40874844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12393885/
Abstract

A neuroanatomical minimal network model was revisited to elucidate the mechanism of salt concentration memory-dependent chemotaxis observed in memorizes the salt concentration during cultivation, manifesting a pronounced taste preference for this concentration. The right-side head sensory neuron, designated ASER, exhibits a response to a decrease in salt concentration. The basal level of glutamate transmission from ASER has been demonstrated to transiently increase and decrease when the current environmental salt concentrations are lower and higher, respectively, than that during previous cultivation. Given the sensitivity of excitatory/inhibitory glutamate receptors expressed on the postsynaptic AIY interneurons, it can be anticipated that the ASER-AIY synaptic transmission will undergo a reversal due to alterations in the basal glutamate release. The neural network, derived from the hypothesis, reproduced the salt concentration memory-dependent preference behavior and revealed that the circuit downstream of ASE functions as a module that is responsible for salt klinotaxis.

摘要

重新审视了一个神经解剖学最小网络模型，以阐明在培养过程中观察到的盐浓度记忆依赖性趋化作用的机制，该模型在培养过程中记住盐浓度，对该浓度表现出明显的味觉偏好。右侧头部感觉神经元，称为ASER，对盐浓度的降低有反应。当当前环境盐浓度分别低于和高于先前培养期间的盐浓度时，已证明来自ASER的谷氨酸传递的基础水平会短暂增加和减少。鉴于在突触后AIY中间神经元上表达的兴奋性/抑制性谷氨酸受体的敏感性，可以预期ASER-AIY突触传递将由于基础谷氨酸释放的改变而发生逆转。从该假设得出的神经网络再现了盐浓度记忆依赖性偏好行为，并揭示了ASE下游的电路作为负责盐趋性的模块发挥作用。

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