Potocka Wiktoria, Assy Zainab, van Tilborg Mirjam M A, Bikker Floris J, Laine Marja L
Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Gustav Mahlerlaan, 3004, Amsterdam, 1081 LA, The Netherlands.
Department of Periodontology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Gustav Mahlerlaan, 3004, Amsterdam, 1081 LA, The Netherlands.
Rheumatol Int. 2025 Aug 28;45(9):209. doi: 10.1007/s00296-025-05958-5.
Sicca syndrome (dry mouth and dry eyes) occurs predominantly due to the side effects of medication, systemic diseases (Sjögren's disease), and radiotherapy of the head and neck region. Sicca complaints decrease the quality of life, cause sleep disturbances, and affect overall health. This systematic literature review investigates the correlation and/or association between dry mouth and dry eyes. A comprehensive search was conducted through PubMed and Web of Science databases up to November 2024. English-language research studies investigating the association and/or correlation between dry mouth and dry eyes were included. Study quality was assessed using NIH quality assessment tools. Data on publication details, participant characteristics, assessment methods, and outcomes was extracted and synthesised based on the type of outcome (objective and/or subjective assessments) and cohort type. Out of 863 records, 27 studies met the eligibility criteria (published 1989-2024), including three observational cohort (n = 942), 15 cross-sectional (n = 6165), and nine case-control (n = 1326 patients, n = 841 controls). 13 studies focused on symptoms in Sjögren's disease, seven in other patient groups, and eight in the general population. Significant correlation and/or association between oral and ocular objective assessments was found in 10 out of 27 studies, and between subjective assessments in 18 out of 19. Within that, 10 out 10 studies assessing self-reported subjective dry mouth and eyes found significant associations. This systematic review provides a general overview of the relationship between dry mouth and dry eyes. It also highlights the need for standardised diagnostic guidelines for dry mouth and dry eyes. PROSPERO registration: CRD42024555796.
干燥综合征（口干和眼干）主要由药物副作用、全身性疾病（干燥综合征）以及头颈部放疗引起。干燥症状会降低生活质量，导致睡眠障碍，并影响整体健康。本系统文献综述调查了口干和眼干之间的相关性和/或关联性。截至2024年11月，通过PubMed和Web of Science数据库进行了全面检索。纳入了调查口干和眼干之间关联和/或相关性的英文研究。使用美国国立卫生研究院质量评估工具评估研究质量。根据结果类型（客观和/或主观评估）和队列类型提取并综合了关于发表细节、参与者特征、评估方法和结果的数据。在863条记录中，27项研究符合纳入标准（发表于1989 - 2024年），包括3项观察性队列研究（n = 942）、15项横断面研究（n = 6165）和9项病例对照研究（n = 1326例患者，n = 841例对照）。13项研究聚焦于干燥综合征患者的症状，7项针对其他患者群体，8项针对普通人群。27项研究中有10项发现口腔和眼部客观评估之间存在显著相关性和/或关联性，19项中有18项发现主观评估之间存在显著相关性和/或关联性。其中，在10项评估自我报告的主观口干和眼干的研究中，均发现了显著关联。本系统综述提供了口干和眼干之间关系的总体概述。它还强调了制定口干和眼干标准化诊断指南的必要性。国际前瞻性系统评价注册库（PROSPERO）注册号：CRD42024555796。
