Nakao K, Higashio T, Inukai T
Jpn J Pharmacol. 1985 Oct;39(2):281-3. doi: 10.1254/jjp.39.281.
Carbamazepine (10 and 20 mg/kg, i.p., P less than 0.01; 40 mg/kg p.o., P less than 0.01), Li2CO3 (200 mg/kg, i.p., P less than 0.01; 200 mg/kg, p.o., P less than 0.05), diazepam (0.5 mg/kg, i.p., P less than 0.01) and haloperidol (0.5 mg/kg, i.p., P less than 0.01) significantly decreased the number of fighting episodes induced by footshock in mice. Picrotoxin (0.3 mg/kg, s.c.) and bicuculline (0.5 mg/kg, s.c.) antagonized the effect of carbamazepine or diazepam completely. Our present results suggest that the taming property of carbamazepine in the footshock model have some relation with the GABAergic mechanism.
卡马西平（腹腔注射10和20毫克/千克，P<0.01；口服40毫克/千克，P<0.01）、碳酸锂（腹腔注射200毫克/千克，P<0.01；口服200毫克/千克，P<0.05）、地西泮（腹腔注射0.5毫克/千克，P<0.01）和氟哌啶醇（腹腔注射0.5毫克/千克，P<0.01）显著减少了电击足部诱导的小鼠打斗次数。印防己毒素（皮下注射0.3毫克/千克）和荷包牡丹碱（皮下注射0.5毫克/千克）完全拮抗了卡马西平或地西泮的作用。我们目前的结果表明，卡马西平在电击足部模型中的驯服特性与GABA能机制有一定关系。
