Takayama T, Iioka H, Kosakai H, Hiraoka K, Moriyama I, Ichijo M
Nihon Heikatsukin Gakkai Zasshi. 1985 Apr;21(2):89-93. doi: 10.1540/jsmr1965.21.89.
The calmodulin levels of human and rat myometrium were measured during pregnancy and under estrogen, progesterone administration, and uterine muscle contraction at the same time was also measured. The calmodulin concentration in the uterine muscle was increased as the stage of pregnancy advanced. This increase also intensified the maximum contractility of the uterine muscle together with the increase of growth during pregnancy. The calmodulin levels were increased by the administration of estrogen and this increase was restricted by progesterone. As a result, the adjustment of the calmodulin level by administration of these steroid hormones was found to be a very interesting mechanism for studying the physiology of uterine muscle contractions.
在妊娠期间以及给予雌激素、孕激素的情况下，对人和大鼠子宫肌层的钙调蛋白水平进行了测定，同时还测量了子宫肌收缩情况。随着妊娠阶段的推进，子宫肌中的钙调蛋白浓度升高。这种升高与妊娠期间生长的增加一起，也增强了子宫肌的最大收缩力。给予雌激素会使钙调蛋白水平升高，而这种升高受到孕激素的限制。结果发现，通过给予这些甾体激素来调节钙调蛋白水平是研究子宫肌收缩生理学的一个非常有趣的机制。
