Sopka N V
Kardiologiia. 1985 Nov;25(11):89-92.
The content of Ca2+ was reduced in myocardiocyte mitochondria and sarcoplasmatic reticulum, and increased in the supra-sedimentary fluid following the sedimentation of sarcoplasmatic reticulum in cases of sudden coronary death, an evidence of disturbed Ca2+ deposition in subcellular myocardial fractions and elevated Ca2+ concentration in myocardiocyte sarcoplasm. The demonstrated disturbances of Ca2+ deposition may be responsible for cardiac contractility disorders, and incomplete diastolic relaxation of the myocardium, and thus provide an essential element of thanatogenesis of the sudden coronary death.
在冠心病猝死病例中，心肌细胞线粒体和肌浆网中的钙离子含量降低，而肌浆网沉淀后的上层清液中钙离子含量升高，这表明心肌亚细胞成分中钙离子沉积紊乱，心肌细胞质中钙离子浓度升高。所证实的钙离子沉积紊乱可能是心脏收缩功能障碍和心肌舒张不完全松弛的原因，从而为冠心病猝死的死因形成提供了一个关键因素。
