[Disorder of Ca2+ deposition in the myocardial mitochondria and sarcoplasmic reticulum in sudden death from ischemic heart disease].

The content of Ca2+ was reduced in myocardiocyte mitochondria and sarcoplasmatic reticulum, and increased in the supra-sedimentary fluid following the sedimentation of sarcoplasmatic reticulum in cases of sudden coronary death, an evidence of disturbed Ca2+ deposition in subcellular myocardial fractions and elevated Ca2+ concentration in myocardiocyte sarcoplasm. The demonstrated disturbances of Ca2+ deposition may be responsible for cardiac contractility disorders, and incomplete diastolic relaxation of the myocardium, and thus provide an essential element of thanatogenesis of the sudden coronary death.