Benedetti R G, Linas S L
Kidney Int. 1985 Oct;28(4):621-8. doi: 10.1038/ki.1985.174.
There is considerable controversy about the hemodynamic effect of potassium in hypertension. To determine if K depletion could alter the control of blood pressure, studies were performed in rats with 2-kidney, 1-clip renovascular hypertension (RVH) after 3 to 6 wks of severe and moderate K depletion. After application of a 0.23 mm clip to the left renal artery, rats were placed on a K-replete (KR) (240 mEq/kg), a moderately K-depleted (KDM) (59 mEq/kg), or a severely K-depleted (KDS) (5 mEq/kg) diet. After 3 wks, mean arterial pressure (MAP) reached 154 +/- 3 in KR but only 121 +/- 2 in KDM (P less than 0.01) and 106 +/- 4 mm Hg in KDS (P less than 0.001). After 6 wks, MAP was 160 +/- 8 in KR, but only 132 +/- 5 in KDM (P less than 0.01) and 129 +/- mm Hg in KDS (P less than 0.01). Plasma K at 3 wks was 4.1 +/- .1 in KR, but only 3.5 +/- .1 in KDM (P less than 0.05) and 2.3 +/- .1 mEq/liter in KDS (P less than 0.001). This was associated with an 8% decrease in muscle K in KDM and a 16% decrease in muscle K in KDS. Although KDS animals did not grow during the 6 wks of study, KDM rats gained 60% as much weight at 3 wks, and, by 6 wks, weight gain was comparable in KDM (101 +/- 9) and KR (110 +/- 9 g) animals (P = NS).(ABSTRACT TRUNCATED AT 250 WORDS)
关于钾在高血压中的血流动力学效应存在相当大的争议。为了确定钾缺乏是否会改变血压控制，在2肾1夹肾血管性高血压（RVH）大鼠中进行了研究，使其经历3至6周的严重和中度钾缺乏。在左肾动脉应用0.23毫米夹子后，将大鼠置于钾充足（KR）（240毫克当量/千克）、中度钾缺乏（KDM）（59毫克当量/千克）或严重钾缺乏（KDS）（5毫克当量/千克）饮食中。3周后，KR组平均动脉压（MAP）达到154±3，但KDM组仅为121±2（P<0.01），KDS组为106±4毫米汞柱（P<0.001）。6周后，KR组MAP为160±8，但KDM组仅为132±5（P<0.01），KDS组为129±毫米汞柱（P<0.01）。3周时KR组血浆钾为4.1±0.1，但KDM组仅为3.5±0.1（P<0.05），KDS组为2.3±0.1毫克当量/升（P<0.001）。这与KDM组肌肉钾减少8%和KDS组肌肉钾减少16%相关。尽管KDS组动物在6周的研究期间没有生长，但KDM组大鼠在3周时体重增加了60%，到6周时，KDM组（101±9）和KR组（110±9克）动物的体重增加相当（P=无显著差异）。（摘要截断于250字）
