Opsoclonus-myoclonus Syndrome in a Female Breast Cancer Patient: A Case Report and Literature Review.
作者信息
Cipolla Calogero, Gebbia Vittorio, DI Stefano Vincenzo, Messina Christian, Sambataro Daniela, Brighina Filippo, Mesi Chiara, Greco Martina, Cortigiani Andrea, Valerio Maria Rosaria
机构信息
Breast Cancer Unit, Policlinico Paolo Giaccone, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy.
Chair of Medical Oncology, Department of Medicine and Surgery, Kore University of Enna, Enna, Italy;
出版信息
Anticancer Res. 2025 Sep;45(9):4037-4045. doi: 10.21873/anticanres.17761.
BACKGROUND/AIM: Opsoclonus-myoclonus syndrome (OMS) is rarely associated with breast cancer. This paraneoplastic syndrome poses significant diagnostic and therapeutic challenges for physicians.
CASE REPORT
This article discusses a case of a 58-year-old Caucasian woman with complex neurological symptoms identified as paraneoplastic OMS due to non-metastatic breast carcinoma. This autoimmune disorder is associated with onco-neural autoantibodies, precisely type II anti-Ri nuclear antibody (ANNA-2), which targets the intracellular Ri antigen (Ri-PNS) and cross-reacts with two neuron-specific antigens. A multidisciplinary approach involving neurologists played a crucial role in case management. Left breast biopsy revealed a poorly differentiated ductal infiltrating carcinoma of the left breast, with 95% positive estrogen receptors, 12% positive progesterone receptors, HER-2 1+, FISH not amplified, and Ki67 at 50%. The patient underwent quadrant surgery for breast cancer and received hormonal therapy with anastrozole. To date, the patient is cancer-free; however, OMS persists. Neurological treatment did not yield significant or durable results. In conclusion, the medical literature on OMS in patients with breast cancer is fragmentary.
CONCLUSION
This report illustrates the complexity of managing breast cancer patients with OMS and reinforces the critical need for a multidisciplinary approach.
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