Lawrence Janet S
Medicine, Cumberland Infirmary, Carlisle, GBR.
Cureus. 2025 May 25;17(5):e84780. doi: 10.7759/cureus.84780. eCollection 2025 May.
Opsoclonus-myoclonus syndrome (OMS) is a rare neurological condition characterised by uncontrolled eye movements and myoclonus. The pathophysiology is autoimmune, usually due to a paraneoplastic or parainfectious cause. Studies on adult-onset OMS are not extensive, and the lack of awareness contributes to the challenge of its diagnosis. A 37-year-old female presented with nausea, dizziness, chaotic eye movements, and wide gait. Blood tests and imaging were unremarkable, but positive oligoclonal bands and elevated protein were seen in the cerebrospinal fluid analysis. She received betahistine and ondansetron as symptomatic treatment and was diagnosed with OMS. She was treated with intravenous immunoglobulin and had a slow, incomplete recovery with residual uncontrolled eye movements. A month before her presentation, she had been seen by the General Practitioner, was treated with antiemetics, and was referred to ENT. This case illustrates the importance of awareness of OMS in avoiding delay in diagnosis.
眼阵挛-肌阵挛综合征（OMS）是一种罕见的神经系统疾病，其特征为不受控制的眼球运动和肌阵挛。病理生理学机制为自身免疫性，通常由副肿瘤性或副感染性病因引起。关于成人起病的OMS的研究并不广泛，且认识不足导致其诊断面临挑战。一名37岁女性出现恶心、头晕、眼球运动紊乱和步态不稳。血液检查和影像学检查无异常，但脑脊液分析中发现寡克隆带阳性和蛋白升高。她接受了倍他司汀和昂丹司琼作为对症治疗，并被诊断为OMS。她接受了静脉注射免疫球蛋白治疗，恢复缓慢且不完全，仍有残留的不受控制的眼球运动。在她就诊前一个月，全科医生看过她，给予了止吐药治疗，并将她转诊至耳鼻喉科。该病例说明了认识OMS对于避免诊断延误的重要性。
