Käsmann Lukas, Gurtner Ralph, Rennollet Robert, Büntzel Judith, Micke Oliver, Belka Claus, Pazos Montserrat, Mücke Ralph, Rauch Josefine, Hübner Jutta
Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany;
German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.
In Vivo. 2025 Sep-Oct;39(5):2969-2975. doi: 10.21873/invivo.14097.
BACKGROUND/AIM: This study aimed to assess the sex-specific prevalence and patterns of complementary and alternative medicine (CAM) use in patients undergoing radiotherapy, using the standardized questionnaire developed as part of the S3 Guideline on Complementary Medicine in Oncology.
Between August and December 2022, 112 out of 697 eligible cancer patients receiving radiotherapy were prospectively enrolled and completed a structured questionnaire assessing CAM use. The questionnaire included 38 CAM methods classified according to their potential for interactions.
Female participants generally used more CAM methods than male participants (median methods: 3 1, <0.001). The most frequently used CAM methods were vitamin D (46.4%), sports/exercise (33%) and vitamin A/C/E or beta-carotene (25%). At least one of the listed CAM methods was used by 79.5%. At least three of the listed CAM methods were used by 52 (46.4%) patients. Thirty-six (32.1%) and 54 (48.2%) patients used CAM methods with known or potential interactions, while 76 (67.9%) used methods with no known interactions. In addition, a higher number of female patients used uncertain methods or medications compared to males (=0.022). The desire for counseling was very similar between both sexes, with no significant difference (=0.973).
The high rate of CAM utility before radiotherapy, especially among females, and the use of uncertain methods, highlights the need for standardized questionnaires to identify potential interactions. This would help enhance patient safety through structured screening and counseling.
背景/目的：本研究旨在使用作为肿瘤学补充医学S3指南一部分开发的标准化问卷，评估接受放疗患者使用补充和替代医学（CAM）的性别特异性患病率及模式。
2022年8月至12月期间，对697名接受放疗的 eligible癌症患者中的112名进行前瞻性招募，并完成一份评估CAM使用情况的结构化问卷。该问卷包括根据其相互作用可能性分类的38种CAM方法。
女性参与者通常比男性参与者使用更多的CAM方法（中位数方法：3对1，<0.001）。最常用的CAM方法是维生素D（46.4%）、运动/锻炼（33%）和维生素A/C/E或β-胡萝卜素（25%）。79.5%的患者使用了至少一种列出的CAM方法。52名（46.4%）患者使用了至少三种列出的CAM方法。36名（32.1%）和54名（48.2%）患者使用了已知或潜在相互作用的CAM方法，而76名（67.9%）患者使用了无已知相互作用的方法。此外，与男性相比，使用不确定方法或药物的女性患者数量更多（P=0.022）。两性对咨询的需求非常相似，无显著差异（P=0.973）。
放疗前CAM的高使用率，尤其是在女性中，以及不确定方法的使用，凸显了需要标准化问卷来识别潜在相互作用。这将有助于通过结构化筛查和咨询提高患者安全性。
