Mwango Noel, Chirwa Grace, Phalula Dennis, Mzikamanda Rizine, Ozuah Nmazuo, Bulsara Shaun, Hilsenbeck Susan, Hosseinipour Mina, Kaspers Gertjan J L, Rau Rachel, Montealegre Jane, Allen Carl E, McAtee Casey L
Baylor College of Medicine Children's Foundation, Lilongwe, Malawi.
Texas Children's Hospital Global HOPE, Houston, Texas, USA.
Pediatr Blood Cancer. 2025 Nov;72(11):e32005. doi: 10.1002/pbc.32005. Epub 2025 Aug 29.
Acute myeloid leukemia (AML) is most often incurable in low-resource settings. To address this challenge, the International Society of Paediatric Oncology (SIOP) developed an intensity-adapted AML practice guideline in 2019. Here, we present the protocol of an observational-implementation study evaluating the SIOP guideline in Malawi. The purpose of this manuscript is to present a novel application of hybrid effectiveness-implementation designs adaptable to a wide spectrum of pediatric hematology-oncology diseases and contexts. Here, we propose hybrid designs as an option for teams in low-resource settings to evaluate current practice and generate much-needed evidence to inform adoption decisions regarding adapted treatment strategies.
在资源匮乏地区，急性髓系白血病（AML）通常难以治愈。为应对这一挑战，国际儿科肿瘤学会（SIOP）于2019年制定了一项根据强度调整的AML实践指南。在此，我们介绍一项在马拉维评估SIOP指南的观察性实施研究方案。本手稿的目的是展示一种混合有效性-实施设计的新应用，该设计适用于广泛的儿科血液肿瘤疾病和环境。在此，我们提出混合设计，作为资源匮乏地区团队评估当前实践并生成急需证据以指导关于适应性治疗策略采用决策的一种选择。
