Fearns Rachel, Liang Bo
Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Methods Mol Biol. 2025;2948:1-17. doi: 10.1007/978-1-0716-4666-3_1.
Human respiratory syncytial virus (RSV) is a significant human pathogen in infants, young children, older adults, and the immunocompromised. Over the last decade, many important mechanisms contributing to RSV infection, replication, and disease pathogenesis have been revealed, and a body of information has accumulated regarding how RSV proteins modulate molecular signaling and immune responses to infection. In this chapter, we briefly introduce RSV replication and pathogenesis and summarize the state of the RSV vaccine and antiviral compounds in the clinical stages of development. This chapter frames the features of this book and the molecular methods used for understanding RSV interaction with the host.
人呼吸道合胞病毒（RSV）是婴幼儿、老年人以及免疫功能低下者的一种重要人类病原体。在过去十年中，许多有助于RSV感染、复制及疾病发病机制的重要机制已被揭示，并且积累了大量关于RSV蛋白如何调节分子信号传导以及对感染的免疫反应的信息。在本章中，我们简要介绍RSV复制和发病机制，并总结处于临床开发阶段的RSV疫苗和抗病毒化合物的状况。本章勾勒了本书的特点以及用于理解RSV与宿主相互作用的分子方法。
